Protein-PCNA interactions: A DNA-scanning mechanism? Journal Article
| Authors: | Kelman, Z.; Hurwitz, J. |
| Article Title: | Protein-PCNA interactions: A DNA-scanning mechanism? |
| Abstract: | Proliferating-cell nuclear antigen (PCNA) plays an essential role in nucleic-acid metabolism in all eukaryotes. The PCNA protein interacts with a large number of proteins. These proteins can be divided into two groups: the first contains proteins that have a known enzymatic activity; the second contains regulatory proteins that are involved in cell-cycle progression, checkpoint control and cellular differentiation. Interestingly, all of the enzymes known to interact with PCNA either recognize specific structures on DNA or have limited DNA-sequence specificity. Proteins that have low sequence specificities could utilize PCNA as an adapter in order to interact with their DNA substrates. |
| Keywords: | review; nonhuman; cell proliferation; proteins; animals; dna repair; models, biological; protein protein interaction; dna; molecular recognition; growth regulation; binding sites; molecular interaction; cycline; enzymes; nucleic acid metabolism; schizosaccharomyces pombe; proliferating cell nuclear antigen; cell dna; humans; human; priority journal |
| Journal Title: | Trends in Biochemical Sciences |
| Volume: | 23 |
| Issue: | 7 |
| ISSN: | 0968-0004 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1998-07-01 |
| Start Page: | 236 |
| End Page: | 238 |
| Language: | English |
| DOI: | 10.1016/s0968-0004(98)01223-7 |
| PUBMED: | 9697409 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 12 December 2016 -- Source: Scopus |
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