Cytokine gene therapy for human tumors Journal Article
| Authors: | D'Angelica, M.; Fong, Y. |
| Article Title: | Cytokine gene therapy for human tumors |
| Abstract: | Cytokine gene therapy is a potentially powerful antineoplastic strategy. It provides paracrine cytokine secretion in the region of putative tumor antigen that maximizes antitumor immune responses and minimizes systemic toxicity. A wealth of animal experimentation has demonstrated the effectiveness of cytokine gene therapy in a variety of tumor models. Enough evidence has mounted such that human cytokine gene therapy trials are underway throughout the United States and elsewhere. |
| Keywords: | review; methodology; neoplasm; neoplasms; tumor associated leukocyte; interleukin 2; cancer immunotherapy; granulocyte macrophage colony stimulating factor; interleukin 4; interleukin 7; gene transfer; gene vector; genetic vectors; cytokine; cytokines; gamma interferon; cancer vaccine; cancer vaccines; virus rna; gene fusion; ligand; gene therapy; vaccinia virus; interleukin 6; fibroblast; electroporation; tumor vaccine; herpes simplex virus; interleukin 12; retrovirus; tumor necrosis factor; virus vector; adenovirus; virus dna; adeno associated virus; humans; human; biolistic transformation |
| Journal Title: | Surgical Oncology Clinics of North America |
| Volume: | 7 |
| Issue: | 3 |
| ISSN: | 1055-3207 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1998-04-01 |
| Start Page: | 537 |
| End Page: | 563 |
| Language: | English |
| PUBMED: | 9624216 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 12 December 2016 -- Source: Scopus |
