Role of elective lymph node dissection in melanoma Journal Article

  


Authors: Hochwald, S. N.; Coit, D. G.
Article Title: Role of elective lymph node dissection in melanoma
Abstract: In the last several years, much debate has centered on the management of the regional lymph nodes in malignant melanoma. The regional lymph nodes are the most common site of melanoma metastases and surgical excision of these involved nodes is the most effective treatment for either cure or local disease control. The issue still in question is the approach to the clinically negative regional lymph node basin. Retrospective studies have yielded conflicting results regarding the value of routine elective lymph node dissection (ELND) when nodes are clinically negative. Four prospective randomized clinical trials have been completed which have indicated that routine ELND is not worthwhile for the majority of melanoma patients. However, ELND may be associated with improved outcome in certain subgroups of patients: those <60 years age with 1 to 2 mm thick melanomas with or without ulceration. In addition, lymphatic mapping with sentinel lymph node biopsy has become increasingly available and has allowed clinicians an alternative to ELND. In the absence of sentinel lymph node biopsy, the role for ELND in these subgroups of patients is one of the remaining unresolved issues.
Keywords: adult; controlled study; human tissue; treatment outcome; survival analysis; survival rate; retrospective studies; major clinical study; clinical trial; review; cancer recurrence; lymph node metastasis; lymph node dissection; lymphatic metastasis; neoplasm staging; lymph node excision; melanoma; skin neoplasms; randomized controlled trial; biopsy; randomized controlled trials; lymph node biopsy; meta analysis; clinical trials; elective surgery; humans; prognosis; human; male; female; priority journal
Journal Title: Seminars in Surgical Oncology
Volume: 14
Issue: 4
ISSN: 8756-0437
Publisher: John Wiley & Sons  
Date Published: 1998-06-01
Start Page: 276
End Page: 282
Language: English
DOI: 10.1002/(sici)1098-2388(199806)14:4<276::aid-ssu3>3.0.co;2-#
PUBMED: 9588720
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031944994&doi=10.1002%2f%28SICI%291098-2388%28199806%2914%3a4%3c276%3a%3aAID-SSU3%3e3.0.CO%3b2-%23&partnerID=40&md5=8efb285ef38dd3c883971356156e9eb7
Notes: Review -- Export Date: 12 December 2016 -- Source: Scopus
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MSK Authors
  1. Steven N Hochwald
    47 Hochwald
  2. Daniel Coit
    542 Coit
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