SMADs: Mediators and regulators of TGF-β signaling Journal Article
| Authors: | Kretzschmar, M.; Massagué, J. |
| Article Title: | SMADs: Mediators and regulators of TGF-β signaling |
| Abstract: | The discovery of SMAD proteins has allowed the delineation of a mechanism by which TGF-β and related growth factors convey their signals from membrane receptors all the way into the nucleus. SMADs are directly phosphorylated and activated by the receptors and then form heteromeric SMAD-SMAD complexes that move into the nucleus where they orchestrate transcriptional responses. In rapid succession, recent reports have identified different modes of SMAD regulation by phosphorylation and have defined the SMAD domains that mediate SMAD interactions, binding to DNA or transcriptional activation. The recent discovery of antagonistic SMADs and regulatory crosstalk with Ras/MAP-kinase pathways add to our rapidly expanding understanding of this major regulatory network. |
| Keywords: | signal transduction; mitogen activated protein kinase; protein phosphorylation; oncoprotein; dna-binding proteins; review; protein domain; animals; complex formation; transforming growth factor beta; protein dna binding; protein protein interaction; transcription, genetic; structure activity relation; oncogene; dna; transcription regulation; smad proteins; ras protein; trans-activators; cell nucleus; growth factor; repressor proteins; phosphoprotein; receptors, cell surface; basic helix-loop-helix leucine zipper transcription factors; membrane receptor; ca(2+)-calmodulin dependent protein kinase; cancer; humans; priority journal |
| Journal Title: | Current Opinion in Genetics and Development |
| Volume: | 8 |
| Issue: | 1 |
| ISSN: | 0959-437X |
| Publisher: | Elsevier Inc. |
| Date Published: | 1998-02-01 |
| Start Page: | 103 |
| End Page: | 111 |
| Language: | English |
| DOI: | 10.1016/s0959-437x(98)80069-5 |
| PUBMED: | 9529613 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 12 December 2016 -- Source: Scopus |
