Mechanisms of TGF-β signaling from cell membrane to the nucleus Journal Article
| Authors: | Shi, Y.; Massagué, J. |
| Article Title: | Mechanisms of TGF-β signaling from cell membrane to the nucleus |
| Abstract: | TGF-β signaling controls a plethora of cellular responses and figures prominently in animal development. Recent cellular, biochemical, and structural studies have revealed significant insight into the mechanisms of the activation of TGF-β receptors through ligand binding, the activation of Smad proteins through phosphorylation, the transcriptional regulation of target gene expression, and the control of Smad protein activity and degradation. This article reviews these latest advances and presents our current understanding on the mechanisms of TGF-β signaling from cell membrane to the nucleus. |
| Keywords: | signal transduction; mitogen activated protein kinase; protein phosphorylation; dna-binding proteins; review; nonhuman; protein domain; protein function; protein motif; animals; gene targeting; gene expression; smad protein; transforming growth factor beta; carboxy terminal sequence; protein assembly; protein degradation; protein serine threonine kinase; animalia; nucleocytoplasmic transport; transcription regulation; amino terminal sequence; molecular recognition; cell membrane; transforming growth factor beta receptor; receptors, transforming growth factor beta; smad proteins; active transport, cell nucleus; binding site; models, molecular; trans-activators; cell nucleus; bone morphogenetic protein 2; ligand binding; receptor binding; nucleoporin; eukaryotic cells; binding kinetics; humans; priority journal |
| Journal Title: | Cell |
| Volume: | 113 |
| Issue: | 6 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2003-06-01 |
| Start Page: | 685 |
| End Page: | 700 |
| Language: | English |
| DOI: | 10.1016/s0092-8674(03)00432-x |
| PUBMED: | 12809600 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
