DNA gyrase and topoisomerase IV: Biochemical activities, physiological roles during chromosome replication, and drug sensitivities Journal Article

  


Authors: Levine, C.; Hiasa, H.; Marians, K. J.
Article Title: DNA gyrase and topoisomerase IV: Biochemical activities, physiological roles during chromosome replication, and drug sensitivities
Abstract: DNA gyrase and topoisomerase IV are the two type II topoisomerases present in bacteria. Though clearly related, based on amino acid sequence similarity, they each play crucial, but distinct, roles in the cell. Gyrase is involved primarily in supporting nascent chain elongation during replication of the chromosome, whereas topoisomerase IV separates the topologically linked daughter chromosomes during the terminal stage of DNA replication. These different roles can be attributed to differences in the biochemical properties of the two enzymes. The biochemical activities, physiological roles, and drug sensitivities of the enzymes are reviewed.
Keywords: gene deletion; review; nonhuman; dna replication; drug resistance; enzyme activity; dna strand breakage; bacterial proteins; amino acid sequence; enzyme inhibitors; escherichia coli; dna helix; dna topoisomerase (atp hydrolysing); drug sensitivity; chromosomes; chromosome replication; dna topoisomerases, type ii; dna topoisomerase iv; dna topoisomerase; coumarin; coumarins; mechanism; enzyme metabolism; dna supercoiling; salmonella typhimurium; quinolone derivative; quinolones; type ii; priority journal; chromosome decatenation
Journal Title: Biochimica Et Biophysica Acta (BBA) - Gene Structure and Expression
Volume: 1400
Issue: 1-3
ISSN: 0167-4781
Publisher: Elsevier B.V.  
Date Published: 1998-10-01
Start Page: 29
End Page: 43
Language: English
DOI: 10.1016/s0167-4781(98)00126-2
PUBMED: 9748489
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032189275&doi=10.1016%2fS0167-4781%2898%2900126-2&partnerID=40&md5=72fc78b7f2e10abdbca2001cff8562a1
Notes: Review -- Export Date: 12 December 2016 -- Source: Scopus
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MSK Authors
  1. Kenneth Marians
    138 Marians
  2. Hiroshi Hiasa
    21 Hiasa
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