Regulation of ceramide production and apoptosis Journal Article
| Authors: | Kolesnick, R. N.; Krönke, M. |
| Article Title: | Regulation of ceramide production and apoptosis |
| Abstract: | Ceramide is a sphingosine-based lipid signaling molecule that regulates cellular differentiation, proliferation, and apoptosis. The emerging picture suggests that coupling of ceramide to specific signaling cascades is both stimulus and cell-type specific. Ceramide action is determined within the context of other stimuli and by the subcellular topology of its production. Here, we discuss the pathways of ceramide generation and the interaction of ceramide with caspases and other apoptotic signaling cascades. |
| Keywords: | signal transduction; review; nonhuman; animals; protein bcl 2; apoptosis; protein protein interaction; enzyme activation; caspases; tumor necrosis factor receptor; sphingosine; mitochondria; protein kinase; mitochondrion; ceramide; ceramides; sphingomyelin phosphodiesterase; second messenger; bcl-2; cytochrome c; sphingomyelinase; cysteine proteinase; humans; human; priority journal; acylsphingosine deacylase |
| Journal Title: | Annual Review of Physiology |
| Volume: | 60 |
| ISSN: | 0066-4278 |
| Publisher: | Annual Reviews |
| Date Published: | 1998-03-01 |
| Start Page: | 643 |
| End Page: | 665 |
| Language: | English |
| DOI: | 10.1146/annurev.physiol.60.1.643 |
| PUBMED: | 9558480 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 12 December 2016 -- Source: Scopus |
