Chemotherapy for lung cancers: Here to stay Journal Article
| Authors: | Kris, M. G.; Hellmann, M. D.; Chaft, J. E. |
| Article Title: | Chemotherapy for lung cancers: Here to stay |
| Abstract: | Four decades of clinical research document the effectiveness of chemotherapy in patients with lung cancers. Chemotherapeutic agents can improve lung cancer symptoms, lengthen life in most patients with lung cancers, and enhance curability in individuals with locoregional disease when combined with surgery or irradiation. Chemotherapy's effectiveness is enhanced in patients with EGFR-mutant and ALK-positive lung cancers and can "rescue" individuals whose oncogene-driven cancers have become resistant to targeted agents. As immunotherapies become part of the therapeutic armamentarium for lung cancers, chemotherapeutic drugs have the potential to modulate the immune system to enhance the effectiveness of immune check point inhibitors. Even in this era of personalized medicine and targeted therapies, chemotherapeutic agents remain essential components in cancer care. |
| Keywords: | treatment outcome; genetics; mutation; mortality; antineoplastic agents; adjuvant therapy; chemotherapy, adjuvant; neoadjuvant therapy; antineoplastic agent; adenocarcinoma; metabolism; antineoplastic combined chemotherapy protocols; lung neoplasms; epidermal growth factor receptor; receptor, epidermal growth factor; drug resistance; drug resistance, neoplasm; protein tyrosine kinase; immunotherapy; adjuvant chemotherapy; receptor protein-tyrosine kinases; egfr protein, human; chemoradiotherapy; personalized medicine; anaplastic lymphoma kinase; molecularly targeted therapy; neoplasms, squamous cell; molecular targeted therapy; procedures; humans; human; precision medicine |
| Journal Title: | American Society of Clinical Oncology Educational Book |
| Volume: | 34 |
| ISSN: | 1548-8756 |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 2014-01-01 |
| Start Page: | e375 |
| End Page: | e380 |
| Language: | English |
| DOI: | 10.14694/EdBook_AM.2014.34.e375 |
| PUBMED: | 24857127 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 25 January 2017 -- Source: Scopus |
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