Dosimetric aspects of radioimmunotherapy Journal Article

  


Authors: O'Donoghue, J. A.
Article Title: Dosimetric aspects of radioimmunotherapy
Abstract: The therapeutic effect of radioimmunotherapy may be reduced by the interaction between tumor cell proliferation, radioresistance and low dose- rates. Radionuclides with shorter half-lives may be useful when tumor localization is particularly rapid or the uptake of radionuclide into a tumor is restricted by a small number of accessible binding sites. Tumors small in comparison to the radionuclide emission range absorb energy inefficiently. In some circumstances, smaller tumors can be harder to cure than larger ones and there is a range of tumor size where a particular radionuclide is most effective. Long-range emitting radionuclides will be sub-optimal for therapy of microscopic disease and short-range emitters will be sub-optimal for cases where uptake is heterogeneous. Treatments using more than one radionuclide may therefore be optimal. Heterogeneity in tumor dosimetry reduces the therapeutic effect. Tumor cells that experience the least dose are least likely to be sterilized and may act as foci of recurrence. Treatments should be designed to minimize the impact of heterogeneity on tumor response. This suggests that the use of 'cocktails' of radionuclides and targeting vectors, combined modality therapy and possibly fractionation of radioimmunotherapy may be advantageous strategies.
Keywords: cancer radiotherapy; cancer immunotherapy; dosimetry; radiation dose fractionation; malignant neoplastic disease; radioisotope; fractionation; radioimmunotherapy; tumor size; radiobiology; heterogeneity; antibody conjugate; human; priority journal; article; cocktails
Journal Title: Tumor Targeting
Volume: 3
Issue: 2
ISSN: 1351-8488
Publisher: Nature Publishing Group  
Date Published: 1998-01-01
Start Page: 105
End Page: 111
Language: English
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031795498&partnerID=40&md5=87f29ea49682256070e5c437bc5b9c03
Notes: Article -- Export Date: 12 December 2016 -- Source: Scopus