Multicentric osteosarcoma, Rothmund-Thomson syndrome, and secondary nasopharyngeal non-Hodgkin's lymphoma: A case report and review of the literature Journal Article

  

Authors:	Spurney, C.; Gorlick, R.; Meyers, P. A.; Healey, J. H.; Huvos, A. G.
Article Title:	Multicentric osteosarcoma, Rothmund-Thomson syndrome, and secondary nasopharyngeal non-Hodgkin's lymphoma: A case report and review of the literature
Abstract:	Purpose: Rothmund-Thomson syndrome (RTS) is an autosomal recessive disease characterized by poikiloderma, photosensitivity, skeletal deformities, and other changes. It is also associated with an increased risk of malignancies, including osteosarcoma. Sixteen previous cases of RTS and osteosarcoma have been reported. Patient: A patient with RTS in whom multicentric osteosarcoma developed is described. After surgery and chemotherapy, a secondary malignant neoplasm (SMN) developed consistent with nasopharyngeal non-Hodgkin's lymphoma. Results: The patient was treated with anti-CD20 monoclonal antibody and is in complete remission. Conclusion: This is the first report of a patient with RTS treated for osteosarcoma in whom a SMN developed. Potential factors involved in this SMN include genetic predisposition and previous chemotherapy.
Keywords:	osteosarcoma; adolescent; adult; cancer chemotherapy; bone neoplasms; cancer surgery; case report; doxorubicin; methotrexate; antineoplastic agent; cyclophosphamide; vincristine; monoclonal antibody; antigens, cd20; antibodies, monoclonal; nonhodgkin lymphoma; infant, newborn; lymphoma, non-hodgkin; dactinomycin; bleomycin; neoplasms, second primary; nasopharynx cancer; nasopharyngeal neoplasms; multiple cancer; photosensitivity; autosomal recessive disorder; rothmund thomson syndrome; humans; human; male; female; priority journal; article; rothmund-thomson syndrome; non- hodgkin's lymphoma; secondary malignant neoplasm; bone deformation; poikiloderma
Journal Title:	Journal of Pediatric Hematology/Oncology
Volume:	20
Issue:	5
ISSN:	1077-4114
Publisher:	Lippincott Williams & Wilkins
Date Published:	1998-09-01
Start Page:	494
End Page:	497
Language:	English
DOI:	10.1097/00043426-199809000-00018
PUBMED:	9787328
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032468161&doi=10.1097%2f00043426-199809000-00018&partnerID=40&md5=d619144b53257181265730831911b4de
Notes:	Article -- Export Date: 12 December 2016 -- Source: Scopus

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