In vitro detection of occult bone marrow metastases in patients with colorectal cancer hepatic metastases Journal Article
| Authors: | Cohen, A. M.; Garin-Chesa, P.; Hanson, M.; Weyhrauch, K.; Kemeny, N.; Fong, Y.; Paty, P.; Welt, S.; Old, L. |
| Article Title: | In vitro detection of occult bone marrow metastases in patients with colorectal cancer hepatic metastases |
| Abstract: | PURPOSE: The purpose of this study was to assess the immunocytochemical status of bone marrow aspirates from patients with clinically isolated hepatic metastases to test the hypothesis that such findings would allow improved patient selection for liver-directed treatment. METHODS: All patients had biopsy-proven or presumed colorectal cancer metastatic to the liver and were scheduled for an operative procedure for hepatic resection or for hepatic artery catheter and chemotherapy pump implant. Immunocytochemical analysis of bone marrow aspirate smears was performed with a panel of monoclonal antibodies directed toward cytokeratins, Lewis Y antigert and A- 33 colorectal epitopes. RESULTS: Data from 80 patients indicated that bone marrow reactivity was present in 9.5 percent of those with resectable hepatic metastases and in 34 percent of those not resected (P = 0.03). No single monoclonal antibody or combination produced better discrimination. CONCLUSIONS: Presence or absence of presumed occult colorectal cancer cells in the bone marrow of patients with isolated hepatic metastases is biologically interesting, but not useful in selecting or altering patient management. |
| Keywords: | immunohistochemistry; clinical article; controlled study; human tissue; cancer localization; patient selection; liver neoplasms; combined modality therapy; cancer diagnosis; colorectal cancer; bone marrow; tumor markers, biological; monoclonal antibodies; monoclonal antibody; colorectal neoplasms; immunoenzyme techniques; liver metastasis; liver; antibodies, monoclonal; diagnostic value; keratins; bone marrow examination; lewis blood-group system; bone marrow neoplasms; micrometastases; occult cancer; bone marrow metastasis; humans; prognosis; human; article; colorectal hepatic metastases |
| Journal Title: | Diseases of the Colon and Rectum |
| Volume: | 41 |
| Issue: | 9 |
| ISSN: | 0012-3706 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1998-09-01 |
| Start Page: | 1112 |
| End Page: | 1115 |
| Language: | English |
| DOI: | 10.1007/bf02239432 |
| PUBMED: | 9749494 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
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