Role of chest CT in patients with negative chest x-rays referred for hepatic colorectal metastases Journal Article

Authors: Povoski, S. P.; Fong, Y.; Sgouros, S. C.; Kemeny, N. E.; Downey, R. J.; Blumgart, L. H.
Article Title: Role of chest CT in patients with negative chest x-rays referred for hepatic colorectal metastases
Abstract: Background: Hepatic resection is the standard treatment for hepatic colorectal metastases. The lung represents the next most likely site, after the liver, of metastatic disease. Computed tomography (CT) of the chest is more sensitive than is chest x-ray in detecting metastatic lung lesions. However, the usefulness of chest CT in the evaluation of patients before hepatic resection remains uncertain. Methods: One hundred consecutive patients with negative chest x-rays and potentially resectable hepatic colorectal metastases underwent chest CT. Patients with CT findings suggestive of metastatic disease were subjected to thoracotomy or video- assisted thoracic surgery (VATS) before laparotomy and attempted hepatic resection. The operative findings and clinical course were analyzed. Results: Eleven of 100 patients had a positive chest CT. Four of these 11 patients had malignant lesions of the lung (three metastatic colorectal cancers and one primary lung cancer). There was no difference in median total hospital stay (8.5 days [range 7 to 13 days] vs. 8.0 days [range 3 to 49 days]), number of perioperative deaths (0 vs. 2 deaths), or long-term outcome between those patients with a positive chest CT undergoing thoracotomy/VATS and those patients with a negative chest CT. Overall, chest CT provided a positive yield of 4% and a positive predictive value of 36% for the detection of malignant lesions of the lung. Conclusions: Chest CT only minimally improved detection of malignant lesions of the lung over chest x-ray. Thoracotomy/VATS and wedge resection of lung nodules did not adversely affect outcome. The low positive yield and low positive predictive value of chest CT in the setting of a negative chest x-ray places in question the usefulness of routinely performing chest CT as part of the extent-of-disease work-up before hepatic resection.
Keywords: adult; cancer survival; aged; aged, 80 and over; middle aged; survival rate; major clinical study; liver neoplasms; laparotomy; colorectal cancer; metastasis; computer assisted tomography; thoracotomy; lung neoplasms; tomography, x-ray computed; algorithms; prediction; colorectal neoplasms; lung metastasis; hospitalization; tumor recurrence; hepatic metastases; computed tomography; colorectal; pulmonary metastases; humans; human; male; female; article
Journal Title: Annals of Surgical Oncology
Volume: 5
Issue: 1
ISSN: 1068-9265
Publisher: Springer  
Date Published: 1998-01-01
Start Page: 9
End Page: 15
Language: English
DOI: 10.1007/bf02303757
PUBMED: 9524701
PROVIDER: scopus
Notes: Article -- Export Date: 12 December 2016 -- Source: Scopus
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MSK Authors
  1. Leslie H Blumgart
    344 Blumgart
  2. Yuman Fong
    746 Fong
  3. Robert J Downey
    206 Downey
  4. Nancy Kemeny
    359 Kemeny