The total synthesis of spirotryprostatin A Journal Article
| Authors: | Edmondson, S. D.; Danishefsky, S. J. |
| Article Title: | The total synthesis of spirotryprostatin A |
| Abstract: | Eight concise steps suffice for the first total synthesis of the title compound 1, which inhibits the transitions from the G2 and M phases into the next phases of the cell cycle. Key steps in the synthesis are a stereocontrolled oxidative rearrangement of an indole to form the chiral spiroindolinone nucleus and a regioselective sulfoxide elimination. |
| Keywords: | total synthesis; spiro compounds; spirotryprostatin a; diketopiperazines; 2-oxindoles |
| Journal Title: | Angewandte Chemie - International Edition |
| Volume: | 37 |
| Issue: | 8 |
| ISSN: | 1433-7851 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1998-05-04 |
| Start Page: | 1138 |
| End Page: | 1140 |
| Language: | English |
| DOI: | 10.1002/(sici)1521-3773(19980504)37:8<1138::aid-anie1138>3.0.co;2-n |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 12 December 2016 -- Source: Scopus |
