Recurrent SERPINB3 and SERPINB4 mutations in patients who respond to anti-CTLA4 immunotherapy Journal Article
| Authors: | Riaz, N.; Havel, J. J.; Kendall, S. M.; Makarov, V.; Walsh, L. A.; Desrichard, A.; Weinhold, N.; Chan, T. A. |
| Article Title: | Recurrent SERPINB3 and SERPINB4 mutations in patients who respond to anti-CTLA4 immunotherapy |
| Abstract: | Immune checkpoint blockade has shown significant promise as an anticancer treatment, yet the determinants of response are not completely understood. Here we show that somatic mutations in SERPINB3 and SERPINB4 are associated with survival after anti-CTLA4 immunotherapy in two independent cohorts of patients with melanoma (n = 174). Interestingly, serpins are homologs of the well-known ovalbumin antigen and are associated with autoimmunity. Our findings have implications for the personalization of immunotherapy. © 2016 Nature America, Inc., part of Springer Nature. All rights reserved. |
| Journal Title: | Nature Genetics |
| Volume: | 48 |
| Issue: | 11 |
| ISSN: | 1061-4036 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2016-11-01 |
| Start Page: | 1327 |
| End Page: | 1329 |
| Language: | English |
| DOI: | 10.1038/ng.3677 |
| PROVIDER: | scopus |
| PUBMED: | 27668655 |
| PMCID: | PMC5553281 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 December 2016 -- Source: Scopus |
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