Response rates of hepatic arterial infusion pump therapy in patients with metastatic colorectal cancer liver metastases refractory to all standard chemotherapies Journal Article


Authors: Cercek, A.; Boucher, T. M.; Gluskin, J. S.; Aguiló, A.; Chou, J. F.; Connell, L. C.; Capanu, M.; Reidy-Lagunes, D.; D'Angelica, M.; Kemeny, N. E.
Article Title: Response rates of hepatic arterial infusion pump therapy in patients with metastatic colorectal cancer liver metastases refractory to all standard chemotherapies
Abstract: Background and Objectives: To evaluate the role of hepatic arterial infusion (HAI) in patients with metastatic colorectal cancer (mCRC) liver metastases (LM) refractory to oxaliplatin, irinotecan, and fluorouracil-based treatments. Methods: A search identified patients with mCRC treated after tumor progression on at least three standard systemic therapies. Results: One hundred and ten patients met criteria for inclusion (i.e., progression on at least three standard agents). Fifty seven patients had LM-only and 53 patients had LM and low volume extrahepatic metastases (LME). Patients with LM-only and LME had a response rate (RR) of 33% and 36%, median survival of 20 months and 11.4 months, respectively. Patients with LM-only had progression free survival of 6 months and hepatic progression free survival of 7.56 months. In a secondary analysis, 46 patients were RECIST-refractory to all standard therapies: LM-only (n = 24) and LME (n = 22). LM-only and LME had a RR of 29% and 36%, and median survival 17.2 months and 9.1 months, respectively. Conclusions: Patients with refractory mCRC LM can achieve a response to HAI resulting in antitumor activity and improvement in survival. Responses are rarely seen in such heavily treated patients with systemic therapy alone, suggesting a regional directed approach is useful. J. Surg. Oncol. 2016;114:655–663. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.
Keywords: survival; colorectal cancer; refractory; liver metastases; response rates
Journal Title: Journal of Surgical Oncology
Volume: 114
Issue: 6
ISSN: 0022-4790
Publisher: Wiley Blackwell  
Date Published: 2016-11-01
Start Page: 655
End Page: 663
Language: English
DOI: 10.1002/jso.24399
PROVIDER: scopus
PUBMED: 27566258
PMCID: PMC5570459
DOI/URL:
Notes: Article -- Export Date: 6 December 2016 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Joanne Fu-Lou Chou
    155 Chou
  2. Marinela Capanu
    209 Capanu
  3. Diane Lauren Reidy
    149 Reidy
  4. Nancy Kemeny
    357 Kemeny
  5. Louise Catherine Connell
    11 Connell
  6. Ariel Esteban Aguilo
    3 Aguilo