Response rates of hepatic arterial infusion pump therapy in patients with metastatic colorectal cancer liver metastases refractory to all standard chemotherapies Journal Article

   

Authors:	Cercek, A.; Boucher, T. M.; Gluskin, J. S.; Aguiló, A.; Chou, J. F.; Connell, L. C.; Capanu, M.; Reidy-Lagunes, D.; D'Angelica, M.; Kemeny, N. E.
Article Title:	Response rates of hepatic arterial infusion pump therapy in patients with metastatic colorectal cancer liver metastases refractory to all standard chemotherapies
Abstract:	Background and Objectives: To evaluate the role of hepatic arterial infusion (HAI) in patients with metastatic colorectal cancer (mCRC) liver metastases (LM) refractory to oxaliplatin, irinotecan, and fluorouracil-based treatments. Methods: A search identified patients with mCRC treated after tumor progression on at least three standard systemic therapies. Results: One hundred and ten patients met criteria for inclusion (i.e., progression on at least three standard agents). Fifty seven patients had LM-only and 53 patients had LM and low volume extrahepatic metastases (LME). Patients with LM-only and LME had a response rate (RR) of 33% and 36%, median survival of 20 months and 11.4 months, respectively. Patients with LM-only had progression free survival of 6 months and hepatic progression free survival of 7.56 months. In a secondary analysis, 46 patients were RECIST-refractory to all standard therapies: LM-only (n = 24) and LME (n = 22). LM-only and LME had a RR of 29% and 36%, and median survival 17.2 months and 9.1 months, respectively. Conclusions: Patients with refractory mCRC LM can achieve a response to HAI resulting in antitumor activity and improvement in survival. Responses are rarely seen in such heavily treated patients with systemic therapy alone, suggesting a regional directed approach is useful. J. Surg. Oncol. 2016;114:655–663. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.
Keywords:	survival; colorectal cancer; refractory; liver metastases; response rates
Journal Title:	Journal of Surgical Oncology
Volume:	114
Issue:	6
ISSN:	0022-4790
Publisher:	Wiley Blackwell
Date Published:	2016-11-01
Start Page:	655
End Page:	663
Language:	English
DOI:	10.1002/jso.24399
PROVIDER:	scopus
PUBMED:	27566258
PMCID:	PMC5570459
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983605207&partnerID=40&md5=c099e393cd92c14e1545fd8212f56afc
Notes:	Article -- Export Date: 6 December 2016 -- Source: Scopus

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