Updated long-term survival for patients with metastatic colorectal cancer treated with liver resection followed by hepatic arterial infusion and systemic chemotherapy Journal Article

   

Authors:	Kemeny, N. E.; Chou, J. F.; Boucher, T. M.; Capanu, M.; DeMatteo, R. P.; Jarnagin, W. R.; Allen, P. J.; Fong, Y.; Cercek, A.; D'Angelica, M. I.
Article Title:	Updated long-term survival for patients with metastatic colorectal cancer treated with liver resection followed by hepatic arterial infusion and systemic chemotherapy
Abstract:	Background and Objectives: Patients who undergo liver resection for metastatic colorectal cancer (mCRC) have reported 5-year survivals ranging from 25% to 50%. The current study updated long-term survival for patients with resected liver metastases treated with adjuvant hepatic arterial infusion (HAI) and systemic (SYS) chemotherapy. Methods: Updated survival and recurrence free survival for patients treated on four consecutive adjuvant protocols with HAI and SYS from 1991 to 2009. Patients were divided into two groups: those treated on protocols before 2003 and after 2003. Median follow-up for all patients was 11 years. Results: All 287 patients enrolled in four prospective protocols after liver resection are included. Patients treated before 2003 had a median follow-up of 15 years, 5 and 10-year survivals of 56% [95%CI: 49-64%] and 40% [95%CI: 32-47%], respectively, and median survival of 71 months. Patients treated after 2003 had a median follow-up of 9 years, 5 and 10-year survivals of 78% [95%CI: 70-84%] and 61% [95%CI: 51-70%], respectively, and median survival has not been reached. Conclusions: Survival is improving for patients with mCRC who undergo liver resection. These data support the durability of long-term survival in patients who undergo resection followed by adjuvant HAI and SYS therapy. (C) 2016 Wiley Periodicals, Inc.
Keywords:	survival; fluorouracil; adjuvant therapy; colorectal cancer; recurrence; dexamethasone; irinotecan; surgery; surgical resection; leucovorin; infusion; randomized-trial; 1st-line treatment; combination; liver metastases; hepatic arterial
Journal Title:	Journal of Surgical Oncology
Volume:	113
Issue:	5
ISSN:	0022-4790
Publisher:	Wiley Blackwell
Date Published:	2016-04-01
Start Page:	477
End Page:	484
Language:	English
ACCESSION:	WOS:000375118900002
DOI:	10.1002/jso.24189
PROVIDER:	wos
PUBMED:	26830685
PMCID:	PMC5076474
Notes:	Article -- Source: Wos

https://synapse.mskcc.org/synapse/works/has_related_data_chk/94125