Capturing identity and fate ex vivo: Stem cells from the mouse blastocyst Journal Article

  


Authors: Garg, V.; Morgani, S.; Hadjantonakis, A. K.
Article Title: Capturing identity and fate ex vivo: Stem cells from the mouse blastocyst
Abstract: During mouse preimplantation development, three molecularly, morphologically, and spatially distinct lineages are formed, the embryonic epiblast, the extraembryonic primitive endoderm, and the trophectoderm. Stem cell lines representing each of these lineages have now been derived and can be indefinitely maintained and expanded in culture, providing an unlimited source of material to study the interplay of tissue-specific transcription factors and signaling pathways involved in these fundamental cell fate decisions. Here we outline our current understanding of the derivation, maintenance, and properties of these in vitro stem cell models representing the preimplantation embryonic lineages. © 2016 Elsevier Inc.
Keywords: embryonic stem cells; preimplantation development; epiblast stem cells; extraembryonic stem cells; trophoblast stem cells
Journal Title: Current Topics in Developmental Biology
Volume: 120
ISSN: 0070-2153
Publisher: Academic Press, Elsevier Inc  
Date Published: 2016-01-01
Start Page: 361
End Page: 400
Language: English
DOI: 10.1016/bs.ctdb.2016.04.007
PROVIDER: scopus
PUBMED: 27475857
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84973542721&partnerID=40&md5=e9acc66e88136842565ecbdec8da1c58
Notes: Book Chapter 10 in "Mammalian Preimplantation Development" (ISBN: 978-0-12-801428-8) -- Export Date: 6 December 2016 -- Source: Scopus
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MSK Authors
  1. Anna-Katerina Hadjantonakis
    191 Hadjantonakis
  2. Vidur Garg
    15 Garg
  3. Sophie Maria Christina Morgani
    10 Morgani
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