Treatment outcomes and secondary cancer incidence in young patients with hairy cell leukaemia Journal Article
| Authors: | Getta, B. M.; Woo, K. M.; Devlin, S.; Park, J. H.; Abdel-Wahab, O.; Saven, A.; Rai, K.; Tallman, M. S. |
| Article Title: | Treatment outcomes and secondary cancer incidence in young patients with hairy cell leukaemia |
| Abstract: | Repeated therapy of hairy cell leukaemia (HCL) with treatments that have potential long-term toxicities has raised concerns regarding increased risk for younger patients. We compared clinical outcomes and disease complications in 63 patients with HCL aged ≤40 years at diagnosis with 268 patients >40 years treated at Memorial Sloan Kettering Cancer Center. The rate of complete remission following initial therapy was 87% and 83% (P = 0·71) and estimated 10-year overall survival was 100% and 82% (P = 0·25) in younger and older patients, respectively. Younger patients required therapy earlier and had a significantly shorter time between first and second therapy (median: 63 months vs. 145 months) (P = 0·008). Younger patients required significantly more lines of therapy during follow-up. The 10-year cumulative incidence of secondary malignancies in young and old patients was 0·205 and 0·287, respectively (P = 0·22). The incidence of secondary cancers in patients aged >40 years at diagnosis increased with the number of treatments for HCL (P = 0·018). These results highlight that young patients with HCL have shorter responses to treatment and require more lines of therapy to maintain disease control, while attaining similar long-term survival. This has implications in the design of future clinical trials given our findings that secondary malignancies increase with more chemotherapy exposure. © 2016 John Wiley & Sons Ltd |
| Keywords: | outcome; young; secondary malignancy; vemurafenib; hairy cell leukaemia |
| Journal Title: | British Journal of Haematology |
| Volume: | 175 |
| Issue: | 3 |
| ISSN: | 0007-1048 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2016-11-01 |
| Start Page: | 402 |
| End Page: | 409 |
| Language: | English |
| DOI: | 10.1111/bjh.14207 |
| PROVIDER: | scopus |
| PUBMED: | 27351754 |
| PMCID: | PMC5539949 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 December 2016 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work