Disease characteristics and clinical outcomes in patients aged less than 40 with chronic lymphocytic leukemia Journal Article

Authors: Getta, B. M.; Devlin, S.; Park, J. H.; Tallman, M. S.; Berman, E.
Article Title: Disease characteristics and clinical outcomes in patients aged less than 40 with chronic lymphocytic leukemia
Abstract: Outcomes in very young CLL patients (age ≤40) are not well characterized. We compared 71 consecutive patients aged ≤40 with 142 “older” matched patients >40 from our institution and used SEER database as an independent comparison group. Patients in the two age groups were diagnosed at similar Rai stage. At diagnosis, very young patients had a similar rate of adverse cytogenetics, IGHV mutation and ZAP70 expression and had lower beta-2-microglobulin and a lower incidence of second malignancies. There was no difference between the groups with respect to incidence of autoimmune manifestations, family history of lymphoma, time to initiation of CLL therapy, response to therapy, or Richter's transformation. Variables including un-mutated IGHV and elevated LDH were associated with shorter times to treatment initiation in both groups. A trend to longer 5-year survival for very young patients in our institution (93% v 82%, p = 0.082) was validated by SEER data. © 2018
Keywords: adult; cancer survival; controlled study; protein expression; treatment response; aged; major clinical study; clinical feature; cancer staging; cancer diagnosis; cancer incidence; cytogenetics; data base; cancer therapy; age; survival time; family history; lymphoma; lactate dehydrogenase; beta 2 microglobulin; chronic lymphatic leukemia; young; protein kinase zap 70; chronic lymphocytic leukemia; clinical outcome; human; male; female; priority journal; article; richter's transformation
Journal Title: Leukemia Research
Volume: 65
ISSN: 0145-2126
Publisher: Pergamon-Elsevier Science Ltd  
Date Published: 2018-02-01
Start Page: 80
End Page: 85
Language: English
DOI: 10.1016/j.leukres.2017.12.008
PROVIDER: scopus
PUBMED: 29316456
Notes: Article -- Export Date: 1 February 2018 -- Source: Scopus
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MSK Authors
  1. Martin Stuart Tallman
    408 Tallman
  2. Jae Hong Park
    132 Park
  3. Ellin Berman
    91 Berman
  4. Sean McCarthy Devlin
    288 Devlin
  5. Bartlomiej Marcin Getta
    21 Getta