Outcomes after radical prostatectomy in men receiving previous pelvic radiation for non-prostate malignancies Journal Article

Authors: Masterson, T. A.; Wedmid, A.; Sandhu, J. S.; Eastham, J. A.
Article Title: Outcomes after radical prostatectomy in men receiving previous pelvic radiation for non-prostate malignancies
Abstract: Objective: To report the perioperative and functional outcomes of nine patients treated at our institution who had radical prostatectomy (RP) after previous pelvic radiotherapy (RT) for non-prostate malignancies. Patients and Methods: From 1993 to 2007, nine patients had RP after external beam RT for testicular seminoma (six), anorectal cancer (two) and colon cancer (one). Clinical information was obtained from a prospective prostate cancer database. Results: RP was completed with no identifiable injury to adjacent structures in all nine patients. Four patients had significant pelvic fibrosis, and three required bilateral neurovascular bundle (NVB) resection. The NVB was preserved in the remaining six patients, four with good preoperative erectile function. However, no patient recovered erectile function after RP at a median (range) follow-up of 75 (12-172) months. Of seven men continent before RP, four required one or fewer pads daily and three were completely dry, achieving complete urinary control at a median (range) time of 7.5 (2-20) months. Two patients developed an anastomotic stricture, one being associated with concomitant ureteric stricture. Conclusions: RP after pelvic RT for non-prostate malignancies was not associated with increased intraoperative morbidity. However, rates of anastomotic stricture, erectile dysfunction and urinary incontinence appeared to be higher than those reported after RP in men with no previous RT, and comparable with those seen in the salvage RP setting. copyright © 2009 BJU INTERNATIONAL.
Keywords: adult; clinical article; treatment outcome; aged; middle aged; cancer radiotherapy; follow up; pelvis; prospective study; prospective studies; radiotherapy; colonic neoplasms; data base; prostate cancer; postoperative complication; prostatic neoplasms; fibrosis; prostate; intraoperative period; urine incontinence; prostatectomy; colon cancer; colon tumor; prostate tumor; ureter stricture; testis tumor; testicular neoplasms; blood vessel; radical prostatectomy; perioperative period; neoplasms, second primary; second cancer; anus cancer; rectal neoplasms; erectile dysfunction; rectum tumor; urinary incontinence; seminoma; functional status; perioperative complications; anastomotic stricture; neurovascular bundle; pelvic fibrosis; penis erection
Journal Title: BJU International
Volume: 104
Issue: 4
ISSN: 1464-4096
Publisher: Wiley Blackwell  
Date Published: 2009-08-01
Start Page: 482
End Page: 485
Language: English
DOI: 10.1111/j.1464-410X.2009.08428.x
PUBMED: 19239447
PROVIDER: scopus
PMCID: PMC2865893
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: BJINF" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Jaspreet Sandhu
    126 Sandhu
  2. James Eastham
    509 Eastham
  3. Alexei Wedmid
    2 Wedmid