Treatment of large tracheal defects after resection: Laryngotracheal release and tracheal replacement Journal Article


Authors: Kirschbaum, A.; Teymoortash, A.; Suárez, C.; Shah, J. P.; Silver, C. E.; Nixon, I.; Rinaldo, A.; Kowalski, L. P.; Robbins, K. T.; Ferlito, A.
Article Title: Treatment of large tracheal defects after resection: Laryngotracheal release and tracheal replacement
Abstract: Objective Resection with direct tracheal or laryngotracheal anastomosis is the standard procedure employed for treatment of benign stenosis or occasionally primary or secondary tracheal malignancy. Data sources Literature review. Results A tracheal anastomosis usually heals without complications provided that the ends being joined are adequately supplied with blood, an atraumatic suturing technique is used, and the anastomosis does not become infected. It is especially important that the anastomosis is not subjected to tension. Conclusion Various techniques of laryngeal and tracheal release serve to reduce the tension on the anastomosis by mobilizing and reducing the distance between the two segments to be approximated. These techniques can be used in different combinations depending on situation encountered during surgery. In cases where more than 50% of the tracheal length must be excised, prosthetic replacements, autologous tissue transfer and allografts are required. All present various problems. The use of tissue-engineering techniques utilizing autologous stem cells has opened new perspectives for tracheal replacement. Such procedures are still in an experimental state. © 2016 Elsevier Ireland Ltd
Keywords: human tissue; allograft; stem cell; blood; surgery; anastomosis; tension; tissue engineering; trachea; tracheal resection; human; anastomotic tension; laryngotracheal anastomosis; tracheal replacement; prosthesiology
Journal Title: Auris Nasus Larynx
Volume: 43
Issue: 6
ISSN: 0385-8146
Publisher: Elsevier Science, Inc.  
Date Published: 2016-12-01
Start Page: 602
End Page: 608
Language: English
DOI: 10.1016/j.anl.2016.03.009
PROVIDER: scopus
PUBMED: 27085818
PMCID: PMC5152768
DOI/URL:
Notes: Review -- Export Date: 1 November 2016 -- Source: Scopus
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  1. Jatin P Shah
    725 Shah