EZH2 and BCL6 cooperate to assemble CBX8-BCOR complex to repress bivalent promoters, mediate germinal center formation and lymphomagenesis Journal Article

   

Authors:	Béguelin, W.; Teater, M.; Gearhart, M. D.; Calvo Fernández, M. T.; Goldstein, R. L.; Cárdenas, M. G.; Hatzi, K.; Rosen, M.; Shen, H.; Corcoran, C. M.; Hamline, M. Y.; Gascoyne, R. D.; Levine, R. L.; Abdel-Wahab, O.; Licht, J. D.; Shaknovich, R.; Elemento, O.; Bardwell, V. J.; Melnick, A. M.
Article Title:	EZH2 and BCL6 cooperate to assemble CBX8-BCOR complex to repress bivalent promoters, mediate germinal center formation and lymphomagenesis
Abstract:	The EZH2 histone methyltransferase mediates the humoral immune response and drives lymphomagenesis through formation of bivalent chromatin domains at critical germinal center (GC) B cell promoters. Herein we show that the actions of EZH2 in driving GC formation and lymphoma precursor lesions require site-specific binding by the BCL6 transcriptional repressor and the presence of a non-canonical PRC1-BCOR-CBX8 complex. The chromodomain protein CBX8 is induced in GC B cells, binds to H3K27me3 at bivalent promoters, and is required for stable association of the complex and the resulting histone modifications. Moreover, oncogenic BCL6 and EZH2 cooperate to accelerate diffuse large B cell lymphoma (DLBCL) development and combinatorial targeting of these repressors results in enhanced anti-lymphoma activity in DLBCLs. © 2016 Elsevier Inc.
Journal Title:	Cancer Cell
Volume:	30
Issue:	2
ISSN:	1535-6108
Publisher:	Cell Press
Date Published:	2016-08-08
Start Page:	197
End Page:	213
Language:	English
DOI:	10.1016/j.ccell.2016.07.006
PROVIDER:	scopus
PMCID:	PMC5000552
PUBMED:	27505670
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84989961535&partnerID=40&md5=39c48f710afbc2060e0e18adc0868b6b
Notes:	Article -- Export Date: 2 November 2016 -- Source: Scopus

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