Cell membrane proteins modulate the carbon nanotube optical bandgap via surface charge accumulation Journal Article


Authors: Roxbury, D.; Jena, P. V.; Shamay, Y.; Horoszko, C. P.; Heller, D. A.
Article Title: Cell membrane proteins modulate the carbon nanotube optical bandgap via surface charge accumulation
Abstract: Cell adhesion is a protein-mediated process intrinsic to most living organisms. Dysfunction in cell adhesion processes is implicated in various diseases, including thrombosis and metastatic cancers. Using an approach to resolve spectral features from cell membrane-associated photoluminescent single-walled carbon nanotubes, we found that nanotube optical bandgaps respond to the electrostatic potential of the cell surface, which corresponds to cell adhesion properties. We studied the carbon nanotube emission energy response to solution ionic potentials, which suggests sensitivity to local charge accumulation. We conclude that nanotubes respond to cell surface electrostatic potentials that are mediated by membrane proteins, which vary significantly across cell types. These findings portend the optical measurement of surface electrostatic potentials for biophysical measurements and biomedical applications. © 2015 American Chemical Society.
Keywords: fluorescence; nanobiotechnology; optical biophysics; in vivo spectroscopy; live cell measurements; near-infrared sensors
Journal Title: ACS Nano
Volume: 10
Issue: 1
ISSN: 1936-0851
Publisher: American Chemical Society  
Date Published: 2016-01-26
Start Page: 499
End Page: 506
Language: English
DOI: 10.1021/acsnano.5b05438
PROVIDER: scopus
PMCID: PMC4975035
PUBMED: 26654246
DOI/URL:
Notes: Article -- Export Date: 2 November 2016 -- Source: Scopus
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MSK Authors
  1. Daniel Alan Heller
    73 Heller
  2. Prakrit Vaibhav Jena
    24 Jena
  3. Yosef   Shamay
    15 Shamay