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98 Results

Inhibition of wild-type and mutant Bcr-Abl by pyrido-pyrimidine-type small molecule kinase inhibitors

Journal Article

Von Bubnoff, N.; Veach, D. R.; Miller, W. T.; Li, W.; Sänger, J.; Peschel, C.; Bornmann, W. G.; Clarkson, B.; Duyster, J.
Cancer Research (2003)

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Direct evidence that Bcr-Abl tyrosine kinase activity disrupts normal synergistic interactions between kit ligand and cytokines in primary primitive progenitor cells

Journal Article

Strife, A.; Wisniewski, D.; Liu, C.; Lambek, C. L.; Darzynkiewicz, Z.; Silver, R. T.; Clarkson, B.
Molecular Cancer Research (2003)

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A novel pyridopyrimidine inhibitor of Abl kinase is a picomolar inhibitor of Bcr-abl-driven K562 cells and is effective against STI571-resistant Bcr-abl mutants

Journal Article

Huron, D. R.; Gorre, M. E.; Kraker, A. J.; Sawyers, C. L.; Rosen, N.; Moasser, M. M.
Clinical Cancer Research (2003)

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Clinical management of gastrointestinal stromal tumors: Before and after STI-571

Journal Article

DeMatteo, R. P.; Heinrich, M. C.; El-Rifai, W. M.; Demetri, G.
Human Pathology (2002)

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Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases

Journal Article

Wisniewski, D.; Lambek, C. L.; Liu, C.; Strife, A.; Veach, D. R.; Nagar, B.; Young, M. A.; Schindler, T.; Bornmann, W. G.; Bertino, J. R.; more...
Cancer Research (2002)

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Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling

Journal Article

Liang, X.; Wisniewski, D.; Strife, A.; Shivakrupa; Clarkson, B.; Resh, M. D.
Journal of Biological Chemistry (2002)

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BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90