Synapse - Nancy M Arango

Nancy M Arango

Research Focus

Structural Biology; Research Assistant

https://orcid.org/0000-0003-1087-4732

9632

Recent additions – View all

Indazole to 2-cyanoindole scaffold progression for mycobacterial lipoamide dehydrogenase inhibitors achieves extended target residence time and improved antibacterial activity
Journal Article

Sun, S.; Ginn, J.; Kochanczyk, T.; Arango, N.; Jiang, X.; Huggins, D. J.; Bean, J.; Michino, M.; Baxt, L.; Liverton, N.; more...
Angewandte Chemie - International Edition (2024)

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Whole cell active inhibitors of mycobacterial lipoamide dehydrogenase afford selectivity over the human enzyme through tight binding interactions
Journal Article

Ginn, J.; Jiang, X.; Sun, S.; Michino, M.; Huggins, D. J.; Mbambo, Z.; Jansen, R.; Rhee, K. Y.; Arango, N.; Lima, C. D.; more...
ACS Infectious Diseases (2021)

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Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase
Journal Article

Bryk, R.; Arango, N.; Maksymiuk, C.; Balakrishnan, A.; Wu, Y. T.; Wong, C. H.; Masquelin, T.; Hipskind, P.; Lima, C. D.; Nathan, C.
Biochemistry (2013)

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Co-authors at MSK

4

Lima
2

Rothman
1

Bean
1

Doege
1

Eng
1

Kochańczyk
1

Ouerfelli
1

Parlati
1

Paumet
1

Rahimian
1

Sollner
1

Varlamov
1

Volchuk
1

Zhao

Types of Work

Publications

Biochemistry (2)
ACS Infectious Diseases (1)
Angewandte Chemie - International Edition (1)
Chemistry and Biology (1)
Journal of Biological Chemistry (1)
Journal of Cell Biology (1)