Groups

Research Focus

STRUCTURAL BIOLOGY; Non-Stipend Howard Hughes

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1. Chemical tools for probing the Ub/Ubl conjugation cascades

   Review

   Kochańczyk, T.; Fishman, M.; Lima, C. D.
   ChemBioChem (2025)

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2. Indazole to 2-cyanoindole scaffold progression for mycobacterial lipoamide dehydrogenase inhibitors achieves extended target residence time and improved antibacterial activity

   Journal Article

   Sun, S.; Ginn, J.; Kochanczyk, T.; Arango, N.; Jiang, X.; Huggins, D. J.; Bean, J.; Michino, M.; Baxt, L.; Liverton, N.; more...
   Angewandte Chemie - International Edition (2024)

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3. Structural basis for transthiolation intermediates in the ubiquitin pathway

   Journal Article

   Kochańczyk, T.; Hann, Z. S.; Lux, M. C.; Delos Reyes, A. M. V.; Ji, C.; Tan, D. S.; Lima, C. D.
   Nature (2024)

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