Synapse - Xiaoping Chen

Results (12)

eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer

Journal Article

Boyer, J. A.; Rosen, E. Y.; Sharma, M.; Dorso, M. A.; Mai, N.; Amor, C.; Reiter, J. M.; Kannan, R.; Gadal, S.; Xu, J.; more...
Proceedings of the National Academy of Sciences of the United States of America (2025)

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TROP2 expression and therapeutic targeting in uterine carcinosarcoma

Journal Article

Moufarrij, S.; Dopeso, H.; Brown, D. N.; Green, H.; Gill, K.; Tengelin, J.; Brodeur, M. N.; Zammarrelli, W. A. 3rd; Varice, N.; Wu, M.; more...
Gynecologic Oncology (2025)

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Uncoupling of Akt and mTOR signaling drives resistance to Akt inhibition in PTEN loss prostate cancers

Journal Article

Mao, N.; Lee, Y. S.; Salsabeel, N.; Zhang, Z.; Li, D.; Kaur, H.; Chen, X.; Chang, Q.; Mehta, S.; Barnes, J.; more...
Science Advances (2025)

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Concurrent SOS1 and MEK suppression inhibits signaling and growth of NF1-null melanoma

Journal Article

Marasco, M.; Kumar, D.; Seale, T.; Borrego, S. G.; Kaplun, E.; Aricescu, I.; Cole, S.; Qeriqi, B.; Qiu, J.; Chen, X.; more...
Cell Reports Medicine (2024)

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STAT3-driven MAPK activation represents a therapeutic vulnerability in ASCL1 high SCLC

Meeting Abstract

Caeser, R.; Hulton, C.; Costa, E.; Durani, V.; Little, M.; Chen, X.; Tischfield, S. E.; Asher, M.; Kombak, F. E.; Chavan, S. S.; more...
Cancer Research (2022)

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Targeting lysine-specific demethylase 1 rescues major histocompatibility complex class I antigen presentation and overcomes programmed death-ligand 1 blockade resistance in SCLC

Journal Article

Nguyen, E. M.; Taniguchi, H.; Chan, J. M.; Zhan, Y. A.; Chen, X.; Qiu, J.; de Stanchina, E.; Allaj, V.; Shah, N. S.; Uddin, F.; more...
Journal of Thoracic Oncology (2022)

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MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer

Journal Article

Caeser, R.; Hulton, C.; Costa, E.; Durani, V.; Little, M.; Chen, X.; Tischfield, S. E.; Asher, M.; Kombak, F. E.; Chavan, S. S.; more...
iScience (2021)

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Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers

Journal Article

Mao, N.; Zhang, Z.; Lee, Y. S.; Choi, D.; Agudelo Rivera, A.; Li, D.; Lee, C.; Haywood, S.; Chen, X.; Chang, Q.; more...
Nature Communications (2021)

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Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis

Meeting Abstract

Mukherjee, R.; Vanaja, K. G.; Boyer, J. A.; Qiu, J.; Chen, X.; de Stanchina, E.; Chandarlapaty, S.; Levchenko, A.; Rosen, N.
Cancer Research (2020)

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Tumor microenvironment-derived NRG1 promotes antiandrogen resistance in prostate cancer

Journal Article

Zhang, Z.; Karthaus, W. R.; Lee, Y. S.; Gao, V. R.; Wu, C.; Russo, J. W.; Liu, M.; Mota, J. M.; Abida, W.; Linton, E.; more...
Cancer Cell (2020)

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