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William Douglas Tap

  1. "MSK Grad Students"
Formats
  1. Journal Article (18)
  2. Meeting Abstract (10)
Groups
  1. Department of Medicine (28)
  2. MSK Grad Students (28)
  3. Sarcoma Service (28)
  4. Solid Tumor Oncology Division (28)
  5. GSK Faculty (25)
  6. Tow Center for Developmental Oncology (TCDO) (22)

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People
  1. Samuel Singer (18)
  2. Mark Dickson (16)
  3. Aimee Crago (13)
  4. Ping Chi (13)
  5. Ciara Kelly (12)
  6. Cristina Antonescu (12)

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Years
  1. 2025 (2)
  2. 2024 (3)
  3. 2023 (4)
  4. 2022 (6)
  5. 2021 (1)
  6. 2020 (2)

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Publications
  1. Clinical Cancer Research (6)
  2. Annals of Oncology (4)
  3. Journal of Clinical Oncology (3)
  4. Cancer Research (2)
  5. Nature Communications (2)
  6. Cancer Cell (1)

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Publishers
  1. American Association for Cancer Research (9)
  2. Nature Publishing Group (4)
  3. Oxford University Press (4)
  4. American Society of Clinical Oncology (3)
  5. Cell Press (2)
  6. American Medical Association (1)

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Results (28)

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  • Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors
    Journal Article

    Kovatcheva, M.; Klein, M. E.; Tap, W. D.; Koff, A.
    Molecular & Cellular Oncology (2018)

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  • Senescence after growth arrest: A mechanism by which CDK4/6 inhibitors can mediate their activity suppressing tumor progression
    Meeting Abstract

    Koff, A.; Klein, M. E.; Dickson, M. A.; Antonescu, C.; Qin, L. X.; Dooley, S. J.; Schwartz, G.; Crago, A. M.; Singer, S.; Tap, W. D.
    Annals of Oncology (2018)

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  • CDK4 inhibition and senescence: Pathway understanding leads to rational drug combinations
    Meeting Abstract

    Klein, M. E.; Kovatcheva, M.; Dickson, M. A.; Liu, D.; Crago, A. M.; Schwartz, G. K.; Tap, W. D.; Singer, S.; Koff, A.
    Clinical Cancer Research (2018)

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  • ATRX is a regulator of therapy induced senescence in human cells
    Journal Article

    Kovatcheva, M.; Liao, W.; Klein, M. E.; Robine, N.; Geiger, H.; Crago, A. M.; Dickson, M. A.; Tap, W. D.; Singer, S.; Koff, A.
    Nature Communications (2017)

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  • MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition
    Journal Article

    Kovatcheva, M.; Liu, D. D.; Dickson, M. A.; Klein, M. E.; O'Connor, R.; Wilder, F. O.; Socci, N. D.; Tap, W. D.; Schwartz, G. K.; Singer, S.; more...
    Oncotarget (2015)

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  • Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth
    Journal Article

    Ran, L.; Sirota, I.; Cao, Z.; Murphy, D.; Shukla, S.; Xie, Y.; Kaufmann, M. C.; Gao, D.; Zhu, S.; Rossi, F.; more...
    Cancer Discovery (2015)

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  • Dual lineage inhibition of ETV1 and KIT disrupts the ETV1-KIT feed forward circuit and potentiates imatinib antitumor effect in GIST oncogenesis
    Meeting Abstract

    Ran, L.; Sirota, I.; Cao, Z.; Murphy, D.; Shukla, S.; Rossi, F.; Wongvipat, J.; Tap, W. D.; Besmer, P.; Antonescu, C. R.; more...
    Cancer Research (2014)

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  • PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors
    Journal Article

    Lee, W.; Teckie, S.; Wiesner, T.; Ran, L.; Prieto Granada, C. N.; Lin, M.; Zhu, S.; Cao, Z.; Liang, Y.; Sboner, A.; more...
    Nature Genetics (2014)

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