Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors Journal Article
| Authors: | Kovatcheva, M.; Klein, M. E.; Tap, W. D.; Koff, A. |
| Article Title: | Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors |
| Abstract: | Senescence is an irreversible form of growth arrest and is generally considered a favorable outcome of cancer therapies, yet little is known about the molecular events that distinguish this state from readily reversible growth arrest (i.e. quiescence). Recently, we discovered that during therapy induced senescence the chromatin remodeling protein alpha-thalassemia, mental retardation, X-linked (ATRX) represses Harvey rat sarcoma viral oncogene homolog (HRAS), and repression of HRAS is necessary to establish senescence, suggesting how new clinical combinations might be used to achieve durable senescence. |
| Keywords: | expression; cellular senescence; atrx; heterochromatin formation; foci; cdk4 inhibitors; geroconversion; therapy induced senescence |
| Journal Title: | Molecular & Cellular Oncology |
| Volume: | 5 |
| Issue: | 1 |
| ISSN: | 2372-3556 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2018-01-01 |
| Start Page: | e1384882 |
| Language: | English |
| ACCESSION: | WOS:000428756800008 |
| DOI: | 10.1080/23723556.2017.1384882 |
| PROVIDER: | wos |
| PMCID: | PMC5791849 |
| PUBMED: | 29404388 |
| Notes: | Editorial Material -- Source: Wos |
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