Synapse - Francis Sirotnak

Results (184)

Synthesis and antifolate evaluation of the aminopterin analogue with a bicyclo[2.2.2]octane ring in place of the benzene ring

Journal Article

Reynolds, R. C.; Johnson, C. A.; Piper, J. R.; Sirotnak, F. M.
European Journal of Medicinal Chemistry (2001)

Fulltext@MSK | Save

Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts

Journal Article

Motwani, M.; Jung, C.; Sirotnak, F. M.; She, Y.; Shah, M. A.; Gonen, M.; Schwartz, G. K.
Clinical Cancer Research (2001)

Fulltext@MSK | Save

Experimental therapeutics with a new 10-deazaaminopterin in human mesothelioma: Further improving efficacy through structural design, pharmacologic modulation at the level of MRP ATPases, and combined therapy with platinums

Journal Article

Khokhar, N. Z.; She, Y.; Rusch, V. W.; Sirotnak, F. M.
Clinical Cancer Research (2001)

Fulltext@MSK | Save

Phase I and pharmacological study of two schedules of the antifolate edatrexate in combination with cisplatin

Journal Article

Laurie, S. A.; Pfister, D. G.; Kris, M. G.; Tong, W. P.; Chrowowski, G.; Pisters, K. M. W.; Heelan, R. T.; Sirotnak, F. M.
Clinical Cancer Research (2001)

Fulltext@MSK | Save

Potentiation of cytotoxic agents against human tumors in mice by ZD1839 (IressaTM), an inhibitor of EGFR tyrosine kinase, does not require high levels of expression of EGFR