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Francis M Sirotnak

Results (184)

Pralatrexate (PDX) produces durable complete remissions in patients with chemotherapy resistant precursor and peripheral T-Cell lymphomas: Results of the MSKCC phase I/II experience

Meeting Abstract

O'Connor, O. A.; Hamlin, P. A.; Gerecitano, J.; Portlock, C. S.; Noy, A.; Moskowitz, C.; Straus, D. J.; Sarasohn, D.; Dumitrescu, O.; Pappanicholaou, J.; more...
Blood (2006)

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Early phase experience with pralatrexate (10-propargyl-10-deazaaminopterin [PRX]), a novel antifolate with high affinity for the reduced folate carrier, in patients with chemotherapy refractory lymphoproliferative malignancies

Meeting Abstract

O'connor, O.; Hamlin, P.; Neylon, E.; Moskowitz, C.; Portlock, C.; Noy, A.; Sirotnak, F.; Zelenetz, A.; Mould, D.; Horwitz, S.
EJC Supplements (2006)

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The schedule-dependent effects of the novel antifolate pralatrexate and gemcitabine are superior to methotrexate and cytarabine in models of human non-Hodgkin's lymphoma

Journal Article

Toner, L. E.; Vrhovac, R.; Smith, E. A.; Gardner, J.; Heaney, M.; Gonen, M.; Teruya-Feldstein, J.; Sirotnak, F.; O'Connor, O. A.
Clinical Cancer Research (2006)

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Pralatrexate (10-propargyl-10-deazaaminopterin (PRX)), a novel antifolate, effects durable complete remissions (CR) in patients with a diversity of drug resistant T-cell lymphomas with minimal toxicity

Meeting Abstract

O'connor, O.; Hamlin, P. A.; Neylon, E.; Moskowitz, C.; Portlock, C. S.; Straus, D. J.; Noy, A.; Cortelli, B.; Zelenetz, A. D.; Fleisher, M.; more...
Blood (2005)

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Phase 1 study of 10-propargyl-10-deazaaminopterin (PDX, pralatrexate) plus docetaxel in patients with advanced Non-Small Cell Lung Cancer (NSCLC)

Meeting Abstract

Gomez, J.; Azzoli, C.; Krug, L.; Ginsberg, M.; Henry, R.; Tyson, L.; Pizzo, B.; Dunne, M.; Kris, M.; Sirotnak, F.
Lung Cancer (2005)

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Pulsatile administration of the epidermal growth factor receptor inhibitor gefitinib is significantly more effective than continuous dosing for sensitizing tumors to paclitaxel

Journal Article

Solit, D. B.; She, Y.; Lobo, J.; Kris, M. G.; Scher, H. I.; Rosen, N.; Sirotnak, F. M.
Clinical Cancer Research (2005)

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Correlating quantitative gene expression to radiologic response to docetaxel (DTX) in formalin-fixed paraffin-embedded (FFPE) tumor tissue from patients (pts) with metastatic non-small cell lung cancer (NSCLC)

Meeting Abstract

Azzoli, C. G.; Khokhar, N.; Chen, J.; Venkatraman, E.; Kris, M. G.; Sirotnak, F. M.
Journal of Clinical Oncology (2004)

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Maitake beta-glucan MD-fraction enhances bone marrow colony formation and reduces doxorubicin toxicity in vitro

Journal Article

Lin, H.; She, Y. H.; Cassileth, B. R.; Sirotnak, F.; Rundles, S. C.
International Immunopharmacology (2004)

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Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics

Journal Article

Lee, M. D.; She, Y.; Soskis, M. J.; Borella, C. P.; Gardner, J. R.; Hayes, P. A.; Dy, B. M.; Heaney, M. L.; Philips, M. R.; Bornmann, W. G.; more...
Journal of Clinical Investigation (2004)

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Microarray analysis of prostate cancer progression to reduced androgen dependence: Studies in unique models contrasts early and late molecular events

Journal Article

Sirotnak, F. M.; She, Y.; Khokhar, N. Z.; Hayes, P.; Gerald, W.; Scher, H. I.
Molecular Carcinogenesis (2004)

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