Synapse - Marc Ladanyi

Results (69)

A deep multiple instance learning framework improves microsatellite instability detection from tumor next generation sequencing

Journal Article

Ziegler, J.; Hechtman, J. F.; Rana, S.; Ptashkin, R. N.; Jayakumaran, G.; Middha, S.; Chavan, S. S.; Vanderbilt, C.; DeLair, D.; Casanova, J.; more...
Nature Communications (2025)

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Microsatellite instability and mismatch repair deficiency define a distinct subset of lung cancers characterized by smoking exposure, high tumor mutational burden, and recurrent somatic MLH1 inactivation

Journal Article

Yang, S. R.; Gedvilaite, E.; Ptashkin, R.; Chang, J.; Ziegler, J.; Mata, D. A.; Villafania, L. B.; Nafa, K.; Hechtman, J. F.; Benayed, R.; more...
Journal of Thoracic Oncology (2024)

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Microsatellite instability defines a subset of lung cancers with smoking exposure, high tumor mutational burden and MLH1 inactivation

Meeting Abstract

Yang, S. R.; Gedvilaite, E.; Ptashkin, R.; Chang, J.; Ziegler, J.; Mata, D.; Villafania, L. B.; Nafa, K.; Hechtman, J. F.; Benhamida, J.; more...
Journal of Thoracic Oncology (2023)

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Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS

Journal Article

Brannon, A. R.; Jayakumaran, G.; Diosdado, M.; Patel, J.; Razumova, A.; Hu, Y.; Meng, F.; Haque, M.; Sadowska, J.; Murphy, B. J.; more...
Nature Communications (2021)

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Pan-cancer biomarkers: Changing the landscape of molecular testing

Review

Yao, J.; Arcila, M. E.; Ladanyi, M.; Hechtman, J. F.
Archives of Pathology & Laboratory Medicine (2021)

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A performance comparison of commonly used assays to detect RET fusions

Journal Article

Yang, S. R.; Aypar, U.; Rosen, E. Y.; Mata, D. A.; Benayed, R.; Mullaney, K.; Jayakumaran, G.; Zhang, Y.; Frosina, D.; Drilon, A.; more...
Clinical Cancer Research (2021)

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Overcoming MET-dependent resistance to selective RET inhibition in patients with RET fusion-positive lung cancer by combining selpercatinib with crizotinib

Journal Article

Rosen, E. Y.; Johnson, M. L.; Clifford, S. E.; Somwar, R.; Kherani, J. F.; Son, J.; Bertram, A. A.; Davare, M. A.; Gladstone, E.; Ivanova, E. V.; more...
Clinical Cancer Research (2021)

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Kinase fusions drive endocrine resistance in estrogen receptor-positive breast cancer

Meeting Abstract

Liu, B.; Ross, D. S.; Schram, A. M.; Razavi, P.; Lagana, S. M.; Zhang, Y.; Scaltriti, M.; Bromberg, J. F.; Ladanyi, M.; Hyman, D. M.; more...
Cancer Research (2020)

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Rapid assessment of microsatellite instability across a spectrum of tumor types using the IDYLLA system

Meeting Abstract

Momeni-Boroujeni, A.; Arcila, M.; Ferguson, D.; Patel, U.; Chan, R.; Barbee, J.; Zehir, A.; Hechtman, J.; Ladanyi, M.; Nafa, K.
Journal of Molecular Diagnostics (2020)

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Tumor microbiome in colorectal carcinoma: Bacterial enrichment is associated with oncogenic variants within specific signaling pathways

Meeting Abstract

Beech, C.; Vanderbilt, C.; Keshinro, A.; Chen, C.; Kim, J.; Hechtman, J.; Zehir, A.; Bowman, A.; Arcila, M.; Ladanyi, M.; more...
Journal of Molecular Diagnostics (2020)

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