Pan-cancer biomarkers: Changing the landscape of molecular testing Review
| Authors: | Yao, J.; Arcila, M. E.; Ladanyi, M.; Hechtman, J. F. |
| Review Title: | Pan-cancer biomarkers: Changing the landscape of molecular testing |
| Abstract: | Context.-The increasing use of large panel nextgeneration sequencing technologies in clinical settings has facilitated the identification of pan-cancer biomarkers, which can be diagnostic, prognostic, predictive, or most importantly, actionable. Objective.-To discuss recently approved and emerging pan-cancer and multihistology biomarkers as well as testing methodologies. Data Sources.-The US Food and Drug Administration approval documents, National Comprehensive Cancer Network guidelines, literature, and authors' own publications. Conclusions.-Since 2017, the US Food and Drug Administration has approved genotype-directed therapies for pan-cancer biomarkers, including microsatellite instability, neurotrophic receptor kinases fusions, and hightumor mutation burden. Both the importance and rarity of these biomarkers have increased the prevalence of genomic profiling across solid malignancies. As an integral part of the management team of patients with advanced cancer, pathologists need to be aware of these emerging biomarkers, the therapies for which they determine eligibility, and the strengths and pitfalls of the available clinical assays. © 2021 College of American Pathologists. All rights reserved. |
| Journal Title: | Archives of Pathology & Laboratory Medicine |
| Volume: | 145 |
| Issue: | 6 |
| ISSN: | 0003-9985 |
| Publisher: | College of American Pathologists |
| Date Published: | 2021-06-01 |
| Start Page: | 692 |
| End Page: | 698 |
| Language: | English |
| DOI: | 10.5858/arpa.2020-0513-RA |
| PUBMED: | 33373449 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 July 2021 -- Source: Scopus |
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