Synapse - Liang Deng

Results (84)

Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA

Journal Article

Gao, P.; Zillinger, T.; Wang, W.; Ascano, M.; Dai, P.; Hartmann, G.; Tuschl, T.; Deng, L.; Barchet, W.; Patel, D. J.
Cell Reports (2014)

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The autophagy genes ULK1/ULK2 negatively regulate autophagy induction by modified vaccinia virus Ankara and are involved in promoting viral replication

Meeting Abstract

Wang, W.; Serna-Tamayo, C.; Dai, P.; Lindsten, T.; Shuman, S.; Deng, L.
Journal of Investigative Dermatology (2014)

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A novel role for the apoptosis inhibitor ARC in suppressing TNFα-induced regulated necrosis

Journal Article

Kung, G.; Dai, P.; Deng, L.; Kitsis, R. N.
Cell Death and Differentiation (2014)

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Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway

Journal Article

Dai, P.; Wang, W.; Cao, H.; Avogadri, F.; Dai, L.; Drexler, I.; Joyce, J. A.; Li, X. D.; Chen, Z.; Merghoub, T.; more...
PLoS Pathogens (2014)

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Heat-inactivated modified vaccinia virus triggers Type I IFN production and inflammasome activation via cGAS/STING and AIM2-mediated cytosolic DNA sensing pathways

Meeting Abstract

Dai, P.; Wang, W.; Cao, H.; Fitzgerald, K. A.; Nunez, G.; Merghoub, T.; Shuman, S.; Deng, L.
Journal of Investigative Dermatology (2014)

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Dermoscopic findings in cutaneous metastases

Journal Article

Chernoff, K. A.; Marghoob, A. A.; Lacouture, M. E.; Deng, L.; Busam, K. J.; Myskowski, P. L.
JAMA Dermatology (2014)

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Structure-function analysis of STING activation by c[G(2′,5′) pA(3′,5′)p] and targeting by antiviral DMXAA

Journal Article

Gao, P.; Ascano, M.; Zillinger, T.; Wang, W.; Dai, P.; Serganov, A. A.; Gaffney, B. L.; Shuman, S.; Jones, R. A.; Deng, L.; more...
Cell (2013)

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Eradication of melanoma by intratumoral injection of attenuated vaccinia virus requires CD8+ T cells and combination of anti-CTLA-4 blockade and virotherapy enhances therapeutic efficacy in advanced melanoma

Meeting Abstract

Wu, X.; Dai, P.; Wang, W.; Avogadri, F.; Cao, H.; Parikh, T.; Jiang, X.; Halpern, A. C.; Houghton, A. N.; Shuman, S.; more...
Journal of Investigative Dermatology (2013)

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STING (stimulator of interferon genes) is required for the induction of autophagy in conventional dendritic cells and macrophages in response to infection by modified vaccinia virus Ankara

Meeting Abstract

Wang, W.; Parikh, T.; Dai, P.; Gammoh, N.; Ganley, I.; Kim, S.; Vance, R.; Virgin, H. W.; Overholtzer, M.; Shuman, S.; more...
Journal of Investigative Dermatology (2013)

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Modified vaccinia virus Ankara induces type I IFN induction in conventional dendritic cells through a STING-mediated cytosolic DNA sensing pathway that requires IRF3, IRF7 and IFNAR1

Meeting Abstract

Dai, P.; Wang, W.; Cao, H.; Avogadri, F.; Vance, R.; Merghoub, T.; Shuman, S.; Deng, L.
Journal of Investigative Dermatology (2013)

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