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Mark D Chappell

  1. "Sloan Kettering Institute Faculty"
Formats
  1. Journal Article (7)
  2. Meeting Abstract (1)
Groups
  1. Molecular Pharmacology and Chemistry Program Faculty (8)
  2. Sloan Kettering Institute Faculty (8)
  3. Sloan Kettering Institute Postdocs (6)
People
  1. Samuel Danishefsky (8)
  2. Ting-Chao Chou (7)
  3. Chul Lee (6)
  4. Shawn Stachel (6)
  5. Yongbiao Guan (5)
  6. Hong Lin (2)

More People

Years
  1. 2002 (3)
  2. 2001 (2)
  3. 2000 (3)
Publications
  1. Journal of Organic Chemistry (3)
  2. Journal of the American Chemical Society (2)
  3. Organic Letters (2)
  4. Proceedings of the American Association for Cancer Research Annual Meeting (1)
Publishers
  1. American Chemical Society (7)
  2. American Association for Cancer Research (1)

Results (8)

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  • Antitumor efficacy determinants of epothilones
    Meeting Abstract

    Chou, T.; Guan, Y.; Biswas, K.; Chappell, M.; Lin, H.; Danishefsky, S. J.
    Proceedings of the American Association for Cancer Research Annual Meeting (2002)

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  • Probing the SAR of dEpoB via chemical synthesis: A total synthesis evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B
    Journal Article

    Chappell, M. D.; Harris, C. R.; Kuduk, S. D.; Balog, A.; Wu, Z.; Zhang, F.; Lee, C. B.; Stachel, S. J.; Danishefsky, S. J.; Chou, T. C.; more...
    Journal of Organic Chemistry (2002)

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  • Highly concise routes to epothilones: The total synthesis and evaluation of epothilone 490
    Journal Article

    Biswas, K.; Lin, H.; Njardarson, J. T.; Chappell, M. D.; Chou, T. C.; Guan, Y.; Tong, W. P.; He, L.; Horwitz, S. B.; Danishefsky, S. J.
    Journal of the American Chemical Society (2002)

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  • Insights into long-range structural effects on the stereochemistry of aldol condensations: A practical total synthesis of desoxyepothilone F
    Journal Article

    Lee, C. B.; Wu, Z.; Zhang, F.; Chappell, M. D.; Stachel, S. J.; Chou, T. C.; Guan, Y.; Danishefsky, S. J.
    Journal of the American Chemical Society (2001)

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  • On the interactivity of complex synthesis and tumor pharmacology in the drug discovery process: Total synthesis and comparative in vivo evaluations of the 15-aza epothilones
    Journal Article

    Stachel, S. J.; Lee, C. B.; Spassova, M.; Chappell, M. D.; Bornmann, W. G.; Danishefsky, S. J.; Chou, T. C.; Guan, Y.
    Journal of Organic Chemistry (2001)

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  • On the total synthesis and preliminary biological evaluations of 15(R) and 15(S) aza-dEpoB: A Mitsunobu inversion at C15 in pre-epothilone fragments
    Journal Article

    Stachel, S. J.; Chappell, M. D.; Lee, C. B.; Danishefsky, S. J.; Chou, T. C.; He, L.; Horwitz, S. B.
    Organic Letters (2000)

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  • En route to a plant scale synthesis of the promising antitumor agent 12,13-desoxyepothilone B
    Journal Article

    Chappell, M. D.; Stachel, S. J.; Lee, C. B.; Danishefsky, S. J.
    Organic Letters (2000)

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  • Total synthesis and antitumor activity of 12,13-desoxyepothilone F: An unexpected solvolysis problem at C15, mediated by remote substitution at C21
    Journal Article

    Lee, C. B.; Chou, T. C.; Zhang, X.; Wang, Z. G.; Kuduk, S. D.; Chappell, M. D.; Stachel, S. J.; Danishefsky, S. J.
    Journal of Organic Chemistry (2000)

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