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Chander Singh Digwal

Formats
  1. Journal Article (10)
  2. Review (4)
  3. Meeting Abstract (2)
  4. Book Section (1)
Groups
  1. Center for Hematologic Malignancies (17)
  2. GSK Faculty (17)
  3. Hematologic Malignancies Research (17)
  4. Molecular Pharmacology and Chemistry Program Faculty (17)
  5. Sloan Kettering Institute Faculty (17)
  6. Sloan Kettering Institute Postdocs (17)

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People
  1. Gabriela Chiosis (17)
  2. Sahil Sharma (15)
  3. Palak Panchal (10)
  4. Anna Rodina Balingcongan (8)
  5. Suhasini Joshi (8)
  6. Pengrong Yan (7)

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Years
  1. 2025 (1)
  2. 2024 (3)
  3. 2023 (5)
  4. 2022 (2)
  5. 2021 (2)
  6. 2020 (2)

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Publications
  1. Nature Communications (3)
  2. Biomedicines (2)
  3. Blood (1)
  4. Chemistry - A European Journal (1)
  5. Clinical Lymphoma, Myeloma and Leukemia (1)
  6. Cold Spring Harbor Perspectives in Medicine (1)

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Publishers
  1. Nature Publishing Group (4)
  2. Cell Press (2)
  3. MDPI (2)
  4. Academic Press (1)
  5. American Society of Hematology (1)
  6. Blackwell Publishing (1)

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Results (17)

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  • Epichaperomes: Redefining chaperone biology and therapeutic strategies in complex diseases
    Review

    Pasala, C.; Digwal, C. S.; Sharma, S.; Wang, S.; Bubula, A.; Chiosis, G.
    RSC Chemical Biology (2025)

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  • Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation
    Journal Article

    Roychowdhury, T.; McNutt, S. W.; Pasala, C.; Nguyen, H. T.; Thornton, D. T.; Sharma, S.; Botticelli, L.; Digwal, C. S.; Joshi, S.; Yang, N.; more...
    Nature Communications (2024)

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  • N-glycosylation-induced pathologic protein conformations as a tool to guide the selection of biologically active small molecules
    Journal Article

    Magni, A.; Sciva, C.; Castelli, M.; Digwal, C. S.; Rodina, A.; Sharma, S.; Ochiana, S.; Patel, H. J.; Shah, S.; Chiosis, G.; more...
    Chemistry - A European Journal (2024)

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  • Synthesis and characterization of click chemical probes for single-cell resolution detection of epichaperomes in neurodegenerative disorders
    Journal Article

    Bay, S.; Digwal, C. S.; Rodilla Martín, A. M.; Sharma, S.; Stanisavljevic, A.; Rodina, A.; Attaran, A.; Roychowdhury, T.; Parikh, K.; Toth, E.; more...
    Biomedicines (2024)

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  • Unraveling the mechanism of epichaperome modulation by zelavespib: Biochemical insights on target occupancy and extended residence time at the site of action
    Journal Article

    Sharma, S.; Joshi, S.; Kalidindi, T.; Digwal, C. S.; Panchal, P.; Lee, S. G.; Zanzonico, P.; Pillarsetty, N.; Chiosis, G.
    Biomedicines (2023)

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  • Structural and functional complexity of HSP90 in cellular homeostasis and disease
    Review

    Chiosis, G.; Digwal, C. S.; Trepel, J. B.; Neckers, L.
    Nature Reviews Molecular Cell Biology (2023)

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  • How aberrant N-glycosylation can alter protein functionality and ligand binding: An atomistic view
    Journal Article

    Castelli, M.; Yan, P.; Rodina, A.; Digwal, C. S.; Panchal, P.; Chiosis, G.; Moroni, E.; Colombo, G.
    Structure (2023)

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  • Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
    Journal Article

    Rodina, A.; Xu, C.; Digwal, C. S.; Joshi, S.; Patel, Y.; Santhaseela, A. R.; Bay, S.; Merugu, S.; Alam, A.; Yan, P.; more...
    Nature Communications (2023)

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  • Epichaperomes as a gateway to understanding, diagnosing, and treating disease through rebalancing protein-protein interaction networks
    Book Section

    Digwal, C. S.; Sharma, S.; Santhaseela, A. R.; Ginsberg, S. D.; Chiosis, G.
    In Kostic, M.; Jones, L. H. (Eds.) Protein Homeostasis in Drug Discovery: A Chemical Biology Perspective (2023)

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  • Disease-specific interactome alterations via epichaperomics: The case for Alzheimer’s disease
    Review

    Ginsberg, S. D.; Neubert, T. A.; Sharma, S.; Digwal, C. S.; Yan, P.; Timbus, C.; Wang, T.; Chiosis, G.
    FEBS Journal (2022)

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