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Andrew C Koff

  1. "Molecular Biology Program Faculty"
Formats
  1. Journal Article (86)
  2. Meeting Abstract (20)
  3. Book Section (3)
  4. Review (1)
Groups
  1. GSK Faculty (110)
  2. Molecular Biology Program Faculty (110)
  3. Sloan Kettering Institute Faculty (110)
  4. Department of Medicine (26)
  5. Solid Tumor Oncology Division (21)
  6. Surgery (16)

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People
  1. Hiroaki Kiyokawa (11)
  2. Nancy Yeh (11)
  3. Samuel Singer (11)
  4. William Tap (11)
  5. Katia Manova-Todorova (10)
  6. Aimee Crago (9)

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Years
  1. 2025 (1)
  2. 2024 (4)
  3. 2023 (1)
  4. 2022 (3)
  5. 2021 (1)
  6. 2019 (1)

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Publications
  1. Cancer Research (9)
  2. Molecular and Cellular Biology (9)
  3. Journal of Biological Chemistry (7)
  4. Oncogene (5)
  5. Proceedings of the American Association for Cancer Research Annual Meeting (5)
  6. Cancer Cell (4)

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Publishers
  1. American Association for Cancer Research (22)
  2. American Society for Microbiology (9)
  3. Nature Publishing Group (8)
  4. American Society for Biochemistry and Molecular Biology (7)
  5. Cell Press (7)
  6. Oxford University Press (7)

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Results (110)

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  • Phase 2 study of the CDK4 inhibitor abemaciclib in dedifferentiated liposarcoma
    Meeting Abstract

    Dickson, M. A.; Koff, A.; D'Angelo, S. P.; Gounder, M. M.; Keohan, M. L.; Kelly, C. M.; Chi, P.; Antonescu, C. R.; Landa, J.; Qin, L. X.; more...
    Journal of Clinical Oncology (2019)

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  • PDLIM7 and CDH18 regulate the turnover of MDM2 during CDK4/6 inhibitor therapy-induced senescence
    Journal Article

    Klein, M. E.; Dickson, M. A.; Antonescu, C.; Qin, L. X.; Dooley, S. J.; Barlas, A.; Manova, K.; Schwartz, G. K.; Crago, A. M.; Singer, S.; more...
    Oncogene (2018)

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  • CDK4/6 inhibitors: The mechanism of action may not be as simple as once thought
    Journal Article

    Klein, M. E.; Kovatcheva, M.; Davis, L. E.; Tap, W. D.; Koff, A.
    Cancer Cell (2018)

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  • Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors
    Journal Article

    Kovatcheva, M.; Klein, M. E.; Tap, W. D.; Koff, A.
    Molecular & Cellular Oncology (2018)

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  • Senescence after growth arrest: A mechanism by which CDK4/6 inhibitors can mediate their activity suppressing tumor progression
    Meeting Abstract

    Koff, A.; Klein, M. E.; Dickson, M. A.; Antonescu, C.; Qin, L. X.; Dooley, S. J.; Schwartz, G.; Crago, A. M.; Singer, S.; Tap, W. D.
    Annals of Oncology (2018)

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  • CDK4 inhibition and senescence: Pathway understanding leads to rational drug combinations
    Meeting Abstract

    Klein, M. E.; Kovatcheva, M.; Dickson, M. A.; Liu, D.; Crago, A. M.; Schwartz, G. K.; Tap, W. D.; Singer, S.; Koff, A.
    Clinical Cancer Research (2018)

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  • ATRX is a regulator of therapy induced senescence in human cells
    Journal Article

    Kovatcheva, M.; Liao, W.; Klein, M. E.; Robine, N.; Geiger, H.; Crago, A. M.; Dickson, M. A.; Tap, W. D.; Singer, S.; Koff, A.
    Nature Communications (2017)

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  • Progression-free survival among patients with well-differentiated or dedifferentiated liposarcoma treated with CDK4 inhibitor palbociclib: A phase 2 clinical trial
    Journal Article

    Dickson, M. A.; Schwartz, G. K.; Louise Keohan, M.; D'Angelo, S. P.; Gounder, M. M.; Chi, P.; Antonescu, C. R.; Landa, J.; Qin, L. X.; Crago, A. M.; more...
    JAMA Oncology (2016)

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  • Application of molecular biology to individualize therapy for patients with liposarcoma
    Journal Article

    Abbas Manji, G.; Singer, S.; Koff, A.; Schwartz, G. K.
    American Society of Clinical Oncology Educational Book (2015)

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  • MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition
    Journal Article

    Kovatcheva, M.; Liu, D. D.; Dickson, M. A.; Klein, M. E.; O'Connor, R.; Wilder, F. O.; Socci, N. D.; Tap, W. D.; Schwartz, G. K.; Singer, S.; more...
    Oncotarget (2015)

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