Synapse - Neal Rosen

Results (426)

V600EBRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway

Journal Article

Pratilas, C. A.; Taylor, B. S.; Ye, Q.; Viale, A.; Sander, C.; Solit, D. B.; Rosen, N.
Proceedings of the National Academy of Sciences of the United States of America (2009)

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Phosphorylated 4E-BP1 is associated with poor survival in melanoma

Journal Article

O'reilly, K. E.; Warycha, M.; Davies, M. A.; Rodrik, V.; Zhou, X. K.; Yee, H.; Polsky, D.; Pavlick, A. C.; Rosen, N.; Bhardwaj, N.; more...
Clinical Cancer Research (2009)

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Proton MRS detects metabolic changes in hormone sensitive and resistant human prostate cancer models CWR22 and CWR22r

Journal Article

Le, H. C.; Lupu, M.; Kotedia, K.; Rosen, N.; Solit, D.; Koutcher, J. A.
Magnetic Resonance in Medicine (2009)

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A pilot study of everolimus and gefitinib in the treatment of recurrent glioblastoma (GBM)

Journal Article

Kreisl, T. N.; Lassman, A.; Mischel, P. S.; Rosen, N.; Scher, H.; Teruya-Feldstein, J.; Shaffer, D.; Lis, E.; Abrey, L. E.
Journal of Neuro-Oncology (2009)

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Phase II trial of the Hsp90 inhibitor tanespimycin (Tan) + trastuzumab (T) in patients (pts) with HER2-positive metastatic breast cancer (MBC)

Meeting Abstract

Modi, S.; Sugarman, S.; Stopeck, A.; Linden, H.; Ma, W.; Kersey, K.; Johnson, R. G.; Rosen, N.; Hannah, A. L.; Hudis, C. A.
Journal of Clinical Oncology (2008)

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The RAF inhibitor PLX4032 effectively suppresses MAPK signaling in cells harboring mutant BRAF, but nor in cells with upstream activation of the pathway

Meeting Abstract

Poulikakos, P. I.; Joseph, E. W.; Tsai, J.; Bollag, G.; Rosen, N.
Cancer Research (2008)

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IGF-1 induces 4EBP1 phosphorylation and activates cap-dependent translation in a TORC1-independent manner

Meeting Abstract

Miller, S. L.; O'Reilly, K. E. P.; Rosen, N.
Cancer Research (2008)

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PLX4032, a selective inhibitor of RAF kinase activity, inhibits BRAF(V600E) tumor proliferation and MAPK signaling in vitro and in vivo

Meeting Abstract

Joseph, E. W.; Poulikakos, P. I.; Pratilas, C. A.; Halilovic, E.; Lobo, J. M.; Bollag, G.; Tsai, J.; Solit, D. B.; Rosen, N.
Cancer Research (2008)

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Coexistent PI3K mutation in human tumors is associated with decreased dependency on mutant KRAS and MEK/ERK signaling for transformation

Meeting Abstract

Halilovic, E.; She, Q.; Ye, Q.; Solit, D. B.; Rosen, N.
Cancer Research (2008)

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Stimulation of epidermal growth factor (EGFR) or HER-3 mediates resistance to MET tyrosine kinase inhibition in MET-amplified gastric cancer cells

Meeting Abstract

Bachleitner-Hofmann, T.; Sun, M. Y.; Chen, C. L.; Tang, L.; Song, L.; Zeng, Z.; Shah, M.; Christensen, J. G.; Rosen, N.; Solit, D. B.; more...
Cancer Research (2008)

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