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Mahesh Saqcena

Formats
  1. Journal Article (10)
  2. Meeting Abstract (1)
Groups
  1. Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center (11)
  2. Department of Medicine (11)
  3. Division of Subspecialty Medicine (11)
  4. Endocrinology (11)
  5. GSK Faculty (11)
  6. Human Oncology and Pathogenesis Program (11)

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People
  1. James Fagin (11)
  2. Gnana Prakasam Krishnamoorthy (10)
  3. Jeffrey Knauf (8)
  4. Ronald Ghossein (7)
  5. Alan Ho (5)
  6. Brian Untch (4)

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Years
  1. 2025 (1)
  2. 2024 (1)
  3. 2023 (1)
  4. 2022 (3)
  5. 2021 (2)
  6. 2019 (1)

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Publications
  1. Cancer Discovery (2)
  2. Cancer Research (2)
  3. Clinical Cancer Research (1)
  4. Endocrine-Related Cancer (1)
  5. Journal of Clinical Endocrinology and Metabolism (1)
  6. Journal of Clinical Investigation (1)

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Publishers
  1. American Association for Cancer Research (5)
  2. American Society for Clinical Investigation (1)
  3. Biomed Central Ltd (1)
  4. Bioscientifica Ltd (1)
  5. Nature Publishing Group (1)
  6. Oxford University Press (1)

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Results (11)

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  • RBM10 loss promotes metastases by aberrant splicing of cytoskeletal and extracellular matrix mRNAs
    Journal Article

    Krishnamoorthy, G. P.; Glover, A. R.; Untch, B. R.; Sigcha-Coello, N.; Xu, B.; Vukel, D.; Liu, Y.; Tiedje, V.; Pineda, J. M. B.; Berman, K.; more...
    Journal of Experimental Medicine (2025)

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  • Cooperative genomic lesions in HRAS-mutant cancers predict resistance to farnesyltransferase inhibitors
    Journal Article

    Nigam, A.; Krishnamoorthy, G. P.; Chatila, W. K.; Berman, K.; Saqcena, M.; Walch, H.; Venkatramani, M.; Ho, A. L.; Schultz, N.; Fagin, J. A.; more...
    Oncogene (2024)

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  • Genomic and transcriptomic characteristics of metastatic thyroid cancers with exceptional responses to radioactive iodine therapy
    Journal Article

    Boucai, L.; Saqcena, M.; Kuo, F.; Grewal, R. K.; Socci, N.; Knauf, J. A.; Krishnamoorthy, G. P.; Ryder, M.; Ho, A. L.; Ghossein, R. A.; more...
    Clinical Cancer Research (2023)

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  • RBM10 loss in thyroid cancer leads to aberrant splicing of cytoskeletal and extracellular matrix mRNAs and increased metastatic fitness
    Meeting Abstract

    Krishnamoorthy, G. P.; Glover, A.; Untch, B.; Saqcena, M.; Vukel, D.; Berman, K.; Abdel-Wahab, O.; Bradley, R. K.; Knauf, J. A.; Fagin, J. A.
    Cancer Research (2022)

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  • Yap governs a lineage-specific neuregulin1 pathway-driven adaptive resistance to RAF kinase inhibitors
    Journal Article

    Garcia-Rendueles, M. E. R.; Krishnamoorthy, G.; Saqcena, M.; AcunĖƒa-Ruiz, A.; Revilla, G.; de Stanchina, E.; Knauf, J. A.; Lester, R.; Xu, B.; Ghossein, R. A.; more...
    Molecular Cancer (2022)

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  • Characterization of subtypes of BRAF-mutant papillary thyroid cancer defined by their thyroid differentiation score
    Journal Article

    Boucai, L.; Seshan, V.; Williams, M.; Knauf, J. A.; Saqcena, M.; Ghossein, R. A.; Fagin, J. A.
    Journal of Clinical Endocrinology and Metabolism (2022)

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  • Co-inhibition of SMAD and MAPK signaling enhances (124)I uptake in BRAF-mutant thyroid cancers
    Journal Article

    Luckett, K. A.; Cracchiolo, J. R.; Krishnamoorthy, G. P.; Leandro-Garcia, L. J.; Nagarajah, J.; Saqcena, M.; Lester, R.; Im, S. Y.; Zhao, Z.; Lowe, S. W.; more...
    Endocrine-Related Cancer (2021)

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  • SWI/SNF complex mutations promote thyroid tumor progression and insensitivity to redifferentiation therapies
    Journal Article

    Saqcena, M.; Leandro-Garcia, L. J.; Maag, J. L. V.; Tchekmedyian, V.; Krishnamoorthy, G. P.; Tamarapu, P. P.; Tiedje, V.; Reuter, V.; Knauf, J. A.; de Stanchina, E.; more...
    Cancer Discovery (2021)

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  • EIF1AX and RAS mutations cooperate to drive thyroid tumorigenesis through ATF4 and c-MYC
    Journal Article

    Krishnamoorthy, G. P.; Davidson, N. R.; Leach, S. D.; Zhao, Z.; Lowe, S. W.; Lee, G.; Landa, I.; Nagarajah, J.; Saqcena, M.; Singh, K.; more...
    Cancer Discovery (2019)

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  • Tipifarnib inhibits HRAS-driven dedifferentiated thyroid cancers
    Journal Article

    Untch, B. R.; Dos Anjos, V.; Garcia-Rendueles, M. E. R.; Knauf, J. A.; Krishnamoorthy, G. P.; Saqcena, M.; Bhanot, U. K.; Socci, N. D.; Ho, A. L.; Ghossein, R.; more...
    Cancer Research (2018)

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