Research Focus

Former Employee. Molecular Pharmacology Program; Research Associate

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1. Two promoters regulate transcription of the mouse folylpolyglutamate synthetase gene: Three tightly clustered Sp1 sites within the first intron markedly enhance activity of promoter B

   Journal Article

   Chen, J.; Hayes, P.; Roy, K.; Sirotnak, F. M.
   Gene (2000)

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2. Transcription of the mouse RFC-1 gene encoding a folate transporter. Multiplicity and properties of promoters with minimum requirements for their basal activity

   Journal Article

   Tolner, B.; Singh, A.; Esaki, T.; Roy, K.; Sirotnak, F. M.
   Gene (1999)

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3. A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues: Implications for intrinsic antifolate resistance and directional orientation of the transporter within the plasma membrane of tumor cells

   Journal Article

   Roy, K.; Tolner, B.; Chiao, J. H.; Sirotnak, F. M.
   Journal of Biological Chemistry (1998)

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