Synapse - Weiyi Toy

Results (19)

New class of selective estrogen receptor degraders (SERDs): Expanding the toolbox of PROTAC degrons

Journal Article

Wang, L.; Guillen, V. S.; Sharma, N.; Flessa, K.; Min, J.; Carlson, K. E.; Toy, W.; Braqi, S.; Katzenellenbogen, B. S.; Katzenellenbogen, J. A.; more...
ACS Medicinal Chemistry Letters (2018)

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Genomic profiling of ER(+) breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance

Journal Article

Giltnane, J. M.; Hutchinson, K. E.; Stricker, T. P.; Formisano, L.; Young, C. D.; Estrada, M. V.; Nixon, M. J.; Du, L.; Sanchez, V.; Ericsson, P. G.; more...
Science Translational Medicine (2017)

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Activating ESR1 mutations differentially affect the efficacy of ER antagonists

Journal Article

Toy, W.; Weir, H.; Razavi, P.; Lawson, M.; Goeppert, A. U.; Mazzola, A. M.; Smith, A.; Wilson, J.; Morrow, C.; Wong, W. L.; more...
Cancer Discovery (2017)

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Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

Journal Article

Fanning, S. W.; Mayne, C. G.; Dharmarjan, V.; Carlson, K. E.; Martin, T. A.; Novick, S. J.; Toy, W.; Green, B.; Panchamukhi, S.; Katzenellenbogen, B. S.; more...
eLife (2016)

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Determining the role of somatic ERa mutations in acquired hormone (or SERM) resistance

Meeting Abstract

Fanning, S. W.; Mayne, C.; Toy, W.; Shen, Y.; Sharma, A.; Panchamukhi, S.; Nowak, J.; Nettles, K. W.; Chandarlapaty, S.; Katzenellenbogen, J. A.; more...
Cancer Research (2015)

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Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling

Journal Article

Will, M.; Qin, A. C. R.; Toy, W.; Yao, Z.; Rodrik-Outmezguine, V. ; Schneider, C.; Huang, X.; Monian, P.; Jiang, X.; de Stanchina, E.; more...
Cancer Discovery (2014)

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Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS signaling

Meeting Abstract

Will, M.; Toy, W.; Yao, Z.; Poulikakos, P.; Rodrik-Outmezguine, V. ; Schneider, C.; Paul, J.; Baselga, J.; Liu, N.; Rosen, N.; more...
Cancer Research (2013)

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ESR1 ligand-binding domain mutations in hormone-resistant breast cancer

Journal Article

Toy, W.; Shen, Y.; Won, H.; Green, B.; Sakr, R. A.; Will, M.; Li, Z.; Gala, K.; Fanning, S.; King, T. A.; more...
Nature Genetics (2013)

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BAY80-6946 is a potent and selective PI3K inhibitor that induces apoptosis in breast cancers by blocking AKT and non-AKT PI3K effector pathways

Meeting Abstract

Will, M.; Toy, W.; Patel, P.; Rodrik-Outmezguine, V.; Schneider, C.; Paul, J.; Liu, N.; Rosen, N.; Chandarlapaty, S.
European Journal of Cancer (2012)

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