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Weiyi Toy

Formats
  1. Journal Article (14)
  2. Meeting Abstract (5)
Groups
  1. Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center (19)
  2. Breast Medicine Service (19)
  3. Department of Medicine (19)
  4. GSK Faculty (19)
  5. Human Oncology and Pathogenesis Program (19)
  6. Sloan Kettering Institute Postdocs (19)

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People
  1. Sarat Chandarlapaty (19)
  2. Jose Baselga (7)
  3. Pedram Razavi (5)
  4. Michael Berger (4)
  5. Neal Rosen (4)
  6. Edi Brogi (3)

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Years
  1. 2024 (2)
  2. 2021 (1)
  3. 2020 (1)
  4. 2019 (3)
  5. 2018 (4)
  6. 2017 (2)

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Publications
  1. Cancer Research (4)
  2. Cancer Discovery (3)
  3. eLife (2)
  4. ACS Chemical Biology (1)
  5. ACS Medicinal Chemistry Letters (1)
  6. Cancer Cell (1)

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Publishers
  1. American Association for Cancer Research (8)
  2. American Chemical Society (2)
  3. Nature Research (2)
  4. eLife Sciences Publications Ltd. (2)
  5. American Association for the Advancement of Science (1)
  6. American Society for Clinical Investigation (1)

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Results (19)

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  • ESR1 F404 mutations and acquired resistance to fulvestrant in ESR1-mutant breast cancer
    Journal Article

    Kingston, B.; Pearson, A.; Herrera-Abreu, M. T.; Sim, L. X.; Cutts, R. J.; Shah, H.; Moretti, L.; Kilburn, L. S.; Johnson, H.; Macpherson, I. R.; more...
    Cancer Discovery (2024)

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  • Somatic estrogen receptor α mutations that induce dimerization promote receptor activity and breast cancer proliferation
    Journal Article

    Irani, S.; Tan, W.; Li, Q.; Toy, W.; Jones, C.; Gadiya, M.; Marra, A.; Katzenellenbogen, J. A.; Carlson, K. E.; Katzenellenbogen, B. S.; more...
    Journal of Clinical Investigation (2024)

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  • Defining the energetic basis for a conformational switch mediating ligand-independent activation of mutant estrogen receptors in breast cancer
    Journal Article

    Mayne, C. G.; Toy, W.; Carlson, K. E.; Bhatt, T.; Fanning, S. W.; Greene, G. L.; Katzenellenbogen, B. S.; Chandarlapaty, S.; Katzenellenbogen, J. A.; Tajkhorshid, E.
    Molecular Cancer Research (2021)

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  • Alterations in PTEN and ESR1 promote clinical resistance to alpelisib plus aromatase inhibitors
    Journal Article

    Razavi, P.; Dickler, M. N.; Shah, P. D.; Toy, W.; Brown, D. N.; Won, H. H.; Li, B. T.; Shen, R.; Vasan, N.; Modi, S.; more...
    Nature Cancer (2020)

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  • Preclinical anticancer activity of LSZ102, a novel oral selective estrogen receptor degrader targeting wild-type and mutant ER
    Meeting Abstract

    Gaither, L. A.; Yip, C. L. T.; Wang, C.; Toy, W.; Sheng, Q.; Chen, J.; Mishina, Y.; Das, R.; Peukert, S.; Loo, A.; more...
    Cancer Research (2019)

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  • Non-canonical, clinical ESR1 mutations promote resistance to antiestrogen therapies
    Meeting Abstract

    Toy, W.; Carlson, K. E.; Martin, T. A.; Razavi, P.; Berger, M.; Baselga, J.; Greene, G.; Katzenellenbogen, J.; Chandarlapaty, S.
    Cancer Research (2019)

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  • Immunohistochemical analysis of estrogen receptor in breast cancer with ESR1 mutations detected by hybrid capture-based next-generation sequencing
    Journal Article

    Ross, D. S.; Zehir, A.; Brogi, E.; Konno, F.; Krystel-Whittemore, M.; Edelweiss, M.; Berger, M. F.; Toy, W.; Chandarlapaty, S.; Razavi, P.; more...
    Modern Pathology (2019)

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  • Antagonists for constitutively active mutant estrogen receptors: Insights into the roles of antiestrogen-core and side-chain
    Journal Article

    Sharma, A.; Toy, W.; Guillen, V. S.; Sharma, N.; Min, J.; Carlson, K. E.; Mayne, C. G.; Lin, S.; Sabio, M.; Greene, G.; more...
    ACS Chemical Biology (2018)

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  • The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells
    Journal Article

    Fanning, S. W.; Jeselsohn, R.; Dharmarajan, V.; Mayne, C. G.; Karimi, M.; Buchwalter, G.; Houtman, R.; Toy, W.; Fowler, C. E.; Han, R.; more...
    eLife (2018)

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  • Loss of the FAT1 tumor suppressor promotes resistance to CDK4/6 inhibitors via the Hippo pathway
    Journal Article

    Li, Z.; Razavi, P.; Li, Q.; Toy, W.; Liu, B.; Ping, C.; Hsieh, W.; Sanchez-Vega, F.; Brown, D. N.; Da Cruz Paula, A. F.; more...
    Cancer Cell (2018)

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