Synapse - Center for Hematologic Malignancies

Results (13553)

The DOT1L inhibitor EPZ-5676: Safety and activity in relapsed/refractory patients with MLL-rearranged leukemia

Meeting Abstract

Stein, E. M.; Garcia-Manero, G.; Rizzieri, D. A.; Savona, M.; Tibes, R.; Altman, J. K.; Jongen-Lavrencic, M.; Döhner, H.; Armstrong, S.; Pollock, R. M.; more...
Blood (2014)

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AG-221, an oral, selective, first-in-class, potent inhibitor of the IDH2 mutant metabolic enzyme, induces durable remissions in a phase I study in patients with IDH2 mutation positive advanced hematologic malignancies

Meeting Abstract

Stein, E. M.; Altman, J. K.; Collins, R.; DeAngelo, D. J.; Fathi, A. T.; Flinn, I.; Frankel, A.; Levine, R. L.; Medeiros, B. C.; Patel, M.; more...
Blood (2014)

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A phase I study of IMGN529, an antibody-drug conjugate (ADC) targeting CD37, in adult patients with relapsed or refractory B-cell non-Hodgkin's lymphoma (NHL)

Meeting Abstract

Stathis, A.; Freedman, A. S.; Flinn, I. W.; Maddocks, K. J.; Weitman, S.; Berdeja, J. G.; Mejia, A. V.; Zucca, E.; Green, R.; Romanelli, A.; more...
Blood (2014)

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Second allogeneic stem cell transplantation for hematologic malignancies using chemotherapy only cytoreduction with clofarabine, melphalan, and thiotepa

Meeting Abstract

Spitzer, B.; Perales, M. A.; Kernan, N. A.; Prockop, S. E.; Webb, N.; Castro-Malaspina, H.; Papadopoulos, E. B.; Young, J. W.; Scaradavou, A.; Kobos, R.; more...
Blood (2014)

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Characterizing transcriptional and epigenetic signatures induced by FLT3-ITD activation

Meeting Abstract

Spitzer, B.; Guryanova, O. A.; Abdel-Wahab, O.; Kucine, N.; Adli, M.; Berman, J. N.; Meshinchi, S.; Bernstein, B.; Pelossof, R.; Leslie, C.; more...
Blood (2014)

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A systemic xenograft model of Waldenstrom's macroglobulinemia demonstrates the potent anti-tumor effect of second generation CD19 directed chimeric antigen receptor modified T cells in this disease

Meeting Abstract

Smith, E. L.; Palomba, M. L.; Park, J. H.; Brentjens, R. J.
Blood (2014)

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Subsequent hematopoietic stem cell transplantation in belinostat-treated patients with relapsed/refractory peripheral T-cell lymphoma (R/R PTCL)

Meeting Abstract

Shustov, A. R.; Al-Ali, H. K.; Wulf, G.; Hsu, P.; Choi, M. R.; Allen, L. F.; Visser, O. J.; Zachee, P.; Horwitz, S. M.
Blood (2014)

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Targeted therapy of B cell lymphoma with a direct inhibitor of the NF-kappa B subunit c-Rel

Meeting Abstract

Shono, Y.; Tuckett, A. Z.; Liou, H. C.; Ouk, S.; Doubrovina, E.; Doubrovin, M.; Derenzini, E.; Scallion, M. I.; Tsai, J. J.; Smith, O. M.; more...
Blood (2014)

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Treatment with antibiotics containing activity against obligate anaerobes worsens GVHD survival in mice and humans after allogeneic BMT

Meeting Abstract

Shono, Y.; Docampo, M. D.; Smith, O. M.; Gupta, J.; Lieberman, S. R.; Taur, Y.; Honda, K.; van den Brink, M. R. M.; Jenq, R. R.
Blood (2014)

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AG-221, a small molecule mutant IDH2 inhibitor, remodels the epigenetic state of IDH2-mutant cells and induces alterations in self-renewal/differentiation in IDH2-mutant AML model in vivo

Meeting Abstract

Shih, A. H.; Shank, K. R.; Meydan, C.; Intlekofer, A. M.; Ward, P.; Thompson, C. B.; Melnick, A. M.; Travins, J.; Straley, K.; Gliser, C.; more...
Blood (2014)

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