Synapse - GSK Faculty

Results (492)

A phase 1b/2 study evaluating the activity of tinengotinib in combination with androgen receptor pathway inhibitors (ARPIs) in patients with metastatic castration resistant prostate cancer (mCRPC)

Meeting Abstract

Abida, W.; Chen, Y.; McHugh, D. J.; Morris, M. J.; Wu, F.; Peng, P.; Hennessy, K.; Wang, H.; Fan, J.; Zaidi, S.
Journal of Clinical Oncology (2025)

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α-Ketoglutarate dehydrogenase is a therapeutic vulnerability in acute myeloid leukemia

Journal Article

Millman, S. E.; Chaves-Perez, A.; Janaki-Raman, S.; Ho, Y. J.; Morris, J. P. 4th; Narendra, V.; Chen, C. C.; Jackson, B. T.; Yashinskie, J. J.; Mezzadra, R.; more...
Blood (2025)

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An inflammatory biomarker signature of response to CAR-T cell therapy in non-Hodgkin lymphoma

Journal Article

Raj, S. S.; Fei, T.; Fried, S.; Ip, A.; Fein, J. A.; Leslie, L. A.; Alarcon Tomas, A.; Leithner, D.; Peled, J. U.; Corona, M.; more...
Nature Medicine (2025)

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Enhancing the persistence and anti-tumor efficacy of CAR-T and CAR-NK cells through genetic disruption of death receptors

Meeting Abstract

Cohen, T. D.; Yi, F.; Zumbo, P.; Etilib, R.; Arkin, H.; Gormally, M.; Hackett, C. S.; Kropp, K.; Etxeberria, I.; Chandran, S. S.; more...
Transplantation and Cellular Therapy (2025)

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Phase Ib study of PRT543, an oral protein arginine methyltransferase 5 (PRMT5) inhibitor, in patients with advanced splicing factor-mutant myeloid malignancies

Research Letter

Bewersdorf, J. P.; Mi, X.; Lu, B.; Kuykendall, A.; Sallman, D.; Patel, M.; Stevens, D.; Philipovskiy, A.; Sutamtewagul, G.; Masarova, L.; more...
Leukemia (2025)

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Multimodal histopathologic models stratify hormone receptor-positive early breast cancer

Journal Article

Boehm, K. M.; El Nahhas, O. S. M.; Marra, A.; Waters, M.; Jee, J.; Braunstein, L.; Schultz, N.; Selenica, P.; Wen, H. Y.; Weigelt, B.; more...
Nature Communications (2025)

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Adjuvant modified FOLFIRINOX for resected pancreatic adenocarcinoma: Clinical insights and genomic features from a large contemporary cohort

Journal Article

Keane, F.; O’Connor, C.; Moss, D.; Chou, J. F.; Perry, M. A.; Crowley, F.; Saxena, P.; Chan, A.; Schoenfeld, J. D.; Singhal, A.; more...
JNCI: Journal of the National Cancer Institute (2025)

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Phase II trial of nivolumab plus doxorubicin, vinblastine, dacarbazine as frontline therapy in older adults with Hodgkin lymphoma

Journal Article

Torka, P.; Feldman, T.; Savage, K. J.; Ganesan, N.; Drill, E.; Hancock, H.; Davey, T.; Perez, L.; Capadona, C.; Subzwari, S.; more...
Journal of Clinical Oncology (2025)

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Dynamics of immune reconstitution and impact on outcomes across CAR-T cell products in large B-cell lymphoma

Journal Article

Luan, D.; DeWolf, S.; Fei, T.; Raj, S.; Shah, G. L.; Lareau, C. A.; Alhomoud, M.; Salles, G.; Rivas-Delgado, A.; Rejeski, K.; more...
Blood Cancer Discovery (2025)

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Long-term outcomes in patients with advanced intrahepatic cholangiocarcinoma treated with hepatic arterial infusion chemotherapy

Journal Article

Cowzer, D.; Soares, K.; Walch, H.; Gönen, M.; Boucher, T. M.; Do, R. K. G.; Harding, J. J.; Varghese, A. M.; Reidy-Lagunes, D.; Saltz, L.; more...
JNCI: Journal of the National Cancer Institute (2025)

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