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Results (115370)

Phase II, single-arm, open-label study of dostarlimab monotherapy in previously untreated patients with stage II/III dMMR/MSI-H locally advanced rectal cancer

Meeting Abstract

Cercek, A.; Bachet, J. B.; Capdevila, J.; Starling, N.; Chen, E. X.; Di Bartolomeo, M.; Yoshino, T.; Vlahovic, G.; Zografos, E.; O'Donnell, S.; more...
Journal of Clinical Oncology (2023)

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Alliance A022104/NRG-GI010: A randomized phase II trial testing the efficacy of triplet versus doublet chemotherapy to achieve clinical complete response in patients with locally advanced rectal cancer—The Janus Rectal Cancer trial

Meeting Abstract

Smith, J. J.; Dasari, A.; Shi, Q.; Garcia-Aguilar, J.; Sanoff, H. K.; George, T. J.; Hong, T. S.; Yothers, G.; Philip, P. A.; Nelson, G. D.; more...
Journal of Clinical Oncology (2023)

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Alliance A022102: Randomized phase III trial of mFOLFIRINOX +/- nivolumab vs. FOLFOX +/- nivolumab for first-line treatment of metastatic HER2-negative gastroesophageal adenocarcinoma (GEA)

Meeting Abstract

Park, H.; Geyer, S. M.; Klute, K.; Bleeker, J.; King, D.; Strickland, M.; Goodrich, A.; Carlisle, D.; Shergill, A.; O'Reilly, E. M.; more...
Journal of Clinical Oncology (2023)

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Phase 2, multicenter, open-label basket trial of nab -sirolimus for patients with malignant solid tumors harboring pathogenic inactivating alterations in TSC1 or TSC2 genes (PRECISION I)

Meeting Abstract

Iyer, G.; Deming, D. A.; Demeure, M. J.; Federman, N.; McKean, M.; Lee, E. K.; Spira, A. I.; Kwiatkowski, D. J.; Hussein, M. A.; Gordon, E. M.; more...
Journal of Clinical Oncology (2023)

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Alliance A022101: A pragmatic, randomized phase III trial evaluating total ablative therapy for patients with limited metastatic colorectal cancer: Evaluating Radiation, Ablation, and Surgery (ERASur)

Meeting Abstract

Hitchcock, K.; Romesser, P. B.; Shi, Q.; Dixon, J. G.; Gholami, S.; White, S. B.; Wu, C.; Goulet, C. C.; Jee, K. W.; Wright, C. L.; more...
Journal of Clinical Oncology (2023)

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A phase 1, open-label, dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of PF-07799933 (ARRY-440) as a single agent and in combination therapy in participants 16 years and older with advanced solid tumors with BRAF alterations

Meeting Abstract

Beck, J. T. T.; McKean, M.; Gadgeel, S. M.; Bowles, D. W.; Haq, R.; Yaeger, R.; Taylor, M. H.; Maity, A. K.; Drescher, S.; Oliver, C.; more...
Journal of Clinical Oncology (2023)

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BREAKWATER: An open-label, multicenter, randomized, phase 3 study, with a safety lead-in (SLI), of first-line (1L) encorafenib (E) + cetuximab (C) ± chemotherapy (CT) vs standard-of-care (SOC) CT for BRAF V600E-mutant metastatic colorectal cancer (mCRC)

Meeting Abstract

Kopetz, S.; Yoshino, T.; Kim, T. W.; Wasan, H. S.; Van Cutsem, E.; Ciardiello, F.; Maughan, T. S.; Eng, C.; Yaeger, R.; Desai, J.; more...
Journal of Clinical Oncology (2023)

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A phase 1/2 study of CFT1946, a novel, bifunctional degradation activating compound (BIDAC) degrader, of mutant BRAF V600 as monotherapy and in combination with trametinib, in mutant BRAF V600 solid tumors

Meeting Abstract

McKean, M.; Spira, A. I.; Rosen, E.; Subbiah, V.; Moreno, V.; Gambardella, V.; Vieito, M.; Saavedra, O.; Cousin, S.; Cassier, P. A.; more...
Journal of Clinical Oncology (2023)

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TROPION-PanTumor03: Phase 2, multicenter study of datopotamab deruxtecan (Dato-DXd) as monotherapy and in combination with anticancer agents in patients (pts) with advanced/metastatic solid tumors

Meeting Abstract

Janjigian, Y. Y.; Oaknin, A.; Lang, J. M.; Ciombor, K. K.; Ray-Coquard, I. L.; Oza, A. M.; Yonemori, K.; Xu, R. H.; Zhao, J.; Gajavelli, S.; more...
Journal of Clinical Oncology (2023)

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First-in-human clinical trial design of a first-in-class theranostic approach with a peptide-based radioligand targeting CA IX-expressing tumors

Meeting Abstract

Feldman, D. R.; Tran, B.; Emmett, L.; Hofman, M. S.; Olivier, P.; Mahammedi, H.; Galetic, I.; Pokorska-Bocci, A.; Bouisset, F.; Gollmer, K.; more...
Journal of Clinical Oncology (2023)

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