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Clinical safety and activity in a phase I trial of AG-221, a first in class, potent inhibitor of the IDH2-mutant protein, in patients with IDH2 mutant positive advanced hematologic malignancies

Meeting Abstract

Stein, E.; Tallman, M.; Pollyea, D. A.; Flinn, I. W.; Fathi, A. T.; Stone, R. M.; Levine, R. L.; Agresta, S.; Schenkein, D.; Yang, H.; more...
Cancer Research (2014)

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Application of a multiplexed fluorescence microscopy method (MultiOmyx (TM)) to dissect proteomic biomarkers of (18)F-fluorodeoxy-glucose ((18)FDG) uptake in breast cancer

Meeting Abstract

Sood, A.; Miller, A. M.; Ginty, F.; McDonough, E.; Sui, Y. X.; Bordwell, A.; Li, Q.; Kaanumalle, S.; Pang, Z. Y.; Torres, F.; more...
Cancer Research (2014)

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The antitumor effects of PI3K beta inhibitors in PTEN negative prostate cancer are enhanced by inhibition of reactivated PI3K alpha signaling

Meeting Abstract

Schwartz, S.; Carver, B. S.; Wongvipat, J.; Rodrik-Outmezguine, V. ; Destanchina, E.; Trigwell, C.; Barry, S.; Baselga, J.; Chandarlapaty, S.; Scher, H. I.; more...
Cancer Research (2014)

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Acquired resistance to rapamycin and mTOR kinase inhibitors is mediated by non-overlapping mutations in distinct sites in the mTOR protein

Meeting Abstract

Rodrik - Outmezguine, V. S.; Yao, Z.; Mukherjee, R.; Cai, L.; Barratt, D.; Ward, R.; Klinowska, T.; Destanchina, E.; Berger, M.; Baselga, J.; more...
Cancer Research (2014)

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Dual lineage inhibition of ETV1 and KIT disrupts the ETV1-KIT feed forward circuit and potentiates imatinib antitumor effect in GIST oncogenesis

Meeting Abstract

Ran, L.; Sirota, I.; Cao, Z.; Murphy, D.; Shukla, S.; Rossi, F.; Wongvipat, J.; Tap, W. D.; Besmer, P.; Antonescu, C. R.; more...
Cancer Research (2014)

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Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors

Meeting Abstract

Lito, P.; Saborowski, A.; Yue, J.; Solomon, M.; Joseph, E.; Fellman, C.; Ohara, K.; Morikami, K.; Miura, T.; Lucas, C.; more...
Cancer Research (2014)

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Development and validation of a clinical next generation sequencing-based assay for hematologic malignancies

Meeting Abstract

Lipson, D.; Nahas, M. K.; Otto, G. A.; He, J.; Wang, K.; Knapp, K. M.; Brennan, K. W.; Donahue, A. L.; Young, L. E.; Young, G.; more...
Cancer Research (2014)

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Context specific effects of the BRAFV600E mutation on hematopoiesis identifies novel models of BRAF mutant hematopoietic disorders

Meeting Abstract

Kim, E.; Chung, S. S.; Park, J. H.; Chung, Y. R.; Lito, P.; Feldstein, J.; Hu, W. H.; Beguilin, W.; Monette, S.; Duy, C.; more...
Cancer Research (2014)

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SMARCA4 mutations in small cell carcinoma of the ovary

Meeting Abstract

Jelinic, P.; Mueller, J.; Olvera, N.; Dao, F.; Scott, S. N.; Shah, R.; Gao, J. J.; Schultz, N.; Gonen, M.; Soslow, R. A.; more...
Cancer Research (2014)

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A phase II study of afatinib (A) in patients (pts) with metastatic human epidermal growth factor receptor (HER2)-positive trastuzumab (T) refractory esophagogastric (EG) cancer

Meeting Abstract

Janjigian, Y. Y.; Imtiaz, T.; Ilson, D. H.; Solit, D. B.; Berger, M. F.; Vakiani, E.
Cancer Research (2014)

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