Splenic infarction and subsequent splenic rupture in a patient with paroxysmal nocturnal hemoglobinuria and heparin-induced thrombocytopenia Journal Article

  

Authors:	Magnan, H.; Kayton, M. L.; DiMichele, D. M.; Araten, D. J.; Kernan, N. A.; Boulad, F.
Article Title:	Splenic infarction and subsequent splenic rupture in a patient with paroxysmal nocturnal hemoglobinuria and heparin-induced thrombocytopenia
Abstract:	We describe a patient with paroxysmal nocturnal hemoglobinuria (PNH) and no previous history of thrombosis who presented with hepatic venous thromboses and subsequently developed splenic infarction and rupture requiring splenectomy while on anticoagulation therapy for the hepatic thromboses. The patient's anticoagulation was complicated by heparin-induced thrombocytopenia (HIT) highlighting the unique management challenge presented by PNH in combination with HIT. © 2009 Wiley-Liss, Inc.
Keywords:	adolescent; adult; human tissue; treatment response; prednisone; splenectomy; case report; drug withdrawal; treatment duration; computer assisted tomography; spleen; thrombocytopenia; vomiting; hemoglobin; hemoglobin blood level; continuous infusion; enzyme linked immunosorbent assay; ultrasound; abdominal pain; thrombosis; anticoagulants; thrombocyte count; heparin; hospital admission; hospital discharge; lactate dehydrogenase; anticoagulation; drug substitution; cyclosporin a; lactate dehydrogenase blood level; tissue plasminogen activator; spleen infarction; heparin induced thrombocytopenia; paroxysmal nocturnal hemoglobinuria; enoxaparin; fondaparinux; lepirudin; thymocyte antibody; aplastic anemia; epigastric pain; liver vein thrombosis; magnetic resonance angiography; reticulocyte count; spleen rupture; thrombocyte transfusion; hemoglobinuria, paroxysmal; splenic infarction; splenic rupture
Journal Title:	Pediatric Blood and Cancer
Volume:	53
Issue:	3
ISSN:	1545-5009
Publisher:	Wiley Periodicals, Inc
Date Published:	2009-09-01
Start Page:	472
End Page:	474
Language:	English
DOI:	10.1002/pbc.22058
PUBMED:	19415735
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-67651236095&partnerID=40&md5=a3fc0b8394bf83d58155005d18ddf540
Notes:	--- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: PBCEA" - "Source: Scopus"

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