Pilot study to assess safety and clinical outcomes of irreversible electroporation for partial gland ablation in men with prostate cancer Journal Article

   

Authors:	Murray, K. S.; Ehdaie, B.; Musser, J.; Mashni, J.; Srimathveeravalli, G.; Durack, J. C.; Solomon, S. B.; Coleman, J. A.
Article Title:	Pilot study to assess safety and clinical outcomes of irreversible electroporation for partial gland ablation in men with prostate cancer
Abstract:	Purpose: Partial prostate gland ablation is a strategy to manage localized prostate cancer. Irreversible electroporation can ablate localized soft tissues. We describe 30 and 90-day complications and intermediate term functional outcomes in men undergoing prostate gland ablation using irreversible electroporation. Materials and Methods: We reviewed the charts of 25 patients with prostate cancer who underwent prostate gland ablation using irreversible electroporation as a primary procedure and who were followed for at least 6 months. Results: Median followup was 10.9 months. Grade 3 complications occurred in 2 patients including epididymitis (1) and urinary tract infection (1). Fourteen patients experienced grade 2 or lower complications, mainly transient urinary symptoms, hematuria and urinary tract infections. Of 25 patients 4 (16%) had cancer in the zone of ablation on routine followup biopsy at 6 months. Of those with normal urinary function at baseline 88% and 94% reported normal urinary function at 6 and 12 months after prostate gland ablation, respectively. By 12 months only 1 patient with normal erectile function at baseline reported new difficulty with potency and only 2 patients (8%) required a pad for urinary incontinence. Conclusions: Prostate gland ablation with irreversible electroporation is feasible and safe in selected men with localized prostate cancer. Intermediate term urinary and erectile function outcomes appear reasonable. Irreversible electroporation is effective in the ablation of tumor bearing prostate tissue as a majority of men had no evidence of residual cancer on biopsy 6 months after prostate gland ablation.
Keywords:	consensus; ablation techniques; radical prostatectomy; electroporation; model; tissue; trial; efficacy; focal therapy; quality; feasibility; will; functional recovery; of life; organ sparing treatments
Journal Title:	Journal of Urology
Volume:	196
Issue:	3
ISSN:	0022-5347
Publisher:	Elsevier Science, Inc.
Date Published:	2016-09-01
Start Page:	883
End Page:	889
Language:	English
ACCESSION:	WOS:000381272100098
DOI:	10.1016/j.juro.2016.02.2986
PROVIDER:	wos
PUBMED:	27113966
PMCID:	PMC5102502
Notes:	Article -- Source: Wos

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