Extraction and radioiodination of Gingko flavonoids and monitoring the cellular incorporation Journal Article
| Authors: | Aras, O.; Takan, G.; Yurt Kilcar, A.; Biber Muftuler, F. Z. |
| Article Title: | Extraction and radioiodination of Gingko flavonoids and monitoring the cellular incorporation |
| Abstract: | Gingko flavonoids (GFLAs) were isolated from extract Egb761 and radiolabeled with 131I. Quality control and lipophilicity studies for 131I-GFLAs were performed. Cellular incorporation ratios for 131I-GFLAs were investigated. The radiolabeling yield of GFLAs with 131I was 90.69 % ± 3.90 and log P value of 131I-GFLAs was 0.99 ± 0.03 (n = 3). Incorporation of 131I-GFLAs on PC3 and MCF7 cells was satisfactory, whereas higher uptake ratios were observed on PC3 cells. A promising agent for cancer diagnosis is presented. © 2016, Akadémiai Kiadó, Budapest, Hungary. |
| Keywords: | extraction; radioiodination; cellular incorporation; egb761; gingko flavonoids |
| Journal Title: | Journal of Radioanalytical and Nuclear Chemistry |
| Volume: | 310 |
| Issue: | 1 |
| ISSN: | 0236-5731 |
| Publisher: | Springer |
| Date Published: | 2016-10-01 |
| Start Page: | 271 |
| End Page: | 278 |
| Language: | English |
| DOI: | 10.1007/s10967-016-4812-7 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 October 2016 -- Source: Scopus |
