Interstitial infusion of erlotinib in the rodent brain Journal Article
| Authors: | Luther, N.; Karampelas, I.; Souliopoulos, E. P.; Edgar, M. A.; Boockvar, J. A.; Souweidane, M. M. |
| Article Title: | Interstitial infusion of erlotinib in the rodent brain |
| Abstract: | A critical need exists for the development of novel forms of treatment for high-grade glioma. Molecular characterization of high-grade glioma has shown overexpression of the epidermal growth factor receptor, antagonists to which, including erlotinib, may prevent tumor growth. Interstitial infusion is a mode of local delivery which bypasses the blood-brain barrier and utilizes a pressure-dependent gradient to enhance drug uniformity and volume of distribution. Interstitial infusion of erlotinib was performed to the striatum of 12 rats in increasing, therapeutic doses. No evidence of clinical or histopathologic toxicity was found. In this experimental study we demonstrate that interstitial infusion of erlotinib is safe in the rodent brain, and may have potential applicability for the treatment of high-grade glioma. © 2009 Old City Publishing, Inc. |
| Keywords: | histopathology; erlotinib; placebo; drug efficacy; drug safety; nonhuman; drug targeting; glioma; brain neoplasms; animals; animal tissue; animal experiment; animal model; body weight; receptor, epidermal growth factor; drug effect; dose-response relationship, drug; cancer inhibition; drug distribution; brain; glioblastoma; rat; blood brain barrier; drug infusion; rats; rats, nude; egfr; ic 50; quinazolines; convection; infusion; drug delivery system; epidermal growth factor receptor kinase inhibitor; tarceva; corpus striatum; interstitial infusion; neurologic examination; microinjections; neostriatum |
| Journal Title: | Journal of Experimental Therapeutics and Oncology |
| Volume: | 8 |
| Issue: | 2 |
| ISSN: | 1359-4117 |
| Publisher: | Old City Publishing, Inc |
| Date Published: | 2009-01-01 |
| Start Page: | 79 |
| End Page: | 84 |
| Language: | English |
| PUBMED: | 20192114 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 30 November 2010" - "CODEN: JETOF" - "Source: Scopus" |
