Interstitial infusion of erlotinib in the rodent brain Journal Article

Authors: Luther, N.; Karampelas, I.; Souliopoulos, E. P.; Edgar, M. A.; Boockvar, J. A.; Souweidane, M. M.
Article Title: Interstitial infusion of erlotinib in the rodent brain
Abstract: A critical need exists for the development of novel forms of treatment for high-grade glioma. Molecular characterization of high-grade glioma has shown overexpression of the epidermal growth factor receptor, antagonists to which, including erlotinib, may prevent tumor growth. Interstitial infusion is a mode of local delivery which bypasses the blood-brain barrier and utilizes a pressure-dependent gradient to enhance drug uniformity and volume of distribution. Interstitial infusion of erlotinib was performed to the striatum of 12 rats in increasing, therapeutic doses. No evidence of clinical or histopathologic toxicity was found. In this experimental study we demonstrate that interstitial infusion of erlotinib is safe in the rodent brain, and may have potential applicability for the treatment of high-grade glioma. © 2009 Old City Publishing, Inc.
Keywords: histopathology; erlotinib; placebo; drug efficacy; drug safety; nonhuman; drug targeting; glioma; brain neoplasms; animals; animal tissue; animal experiment; animal model; body weight; receptor, epidermal growth factor; drug effect; dose-response relationship, drug; cancer inhibition; drug distribution; brain; glioblastoma; rat; blood brain barrier; drug infusion; rats; rats, nude; egfr; ic 50; quinazolines; convection; infusion; drug delivery system; epidermal growth factor receptor kinase inhibitor; tarceva; corpus striatum; interstitial infusion; neurologic examination; microinjections; neostriatum
Journal Title: Journal of Experimental Therapeutics and Oncology
Volume: 8
Issue: 2
ISSN: 1359-4117
Publisher: Old City Publishing, Inc  
Date Published: 2009-01-01
Start Page: 79
End Page: 84
Language: English
PUBMED: 20192114
PROVIDER: scopus
Notes: --- - "Export Date: 30 November 2010" - "CODEN: JETOF" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Mark Allen Edgar
    45 Edgar